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南平市人群血尿酸水平与非酒精性脂肪肝患病关系病例对照研究

陈冰冰 李慧泉 潘欣婷 李扬帆 徐尚华 彭仙娥

陈冰冰, 李慧泉, 潘欣婷, 李扬帆, 徐尚华, 彭仙娥. 南平市人群血尿酸水平与非酒精性脂肪肝患病关系病例对照研究[J]. 中国公共卫生, 2021, 37(6): 1015-1018. doi: 10.11847/zgggws1125545
引用本文: 陈冰冰, 李慧泉, 潘欣婷, 李扬帆, 徐尚华, 彭仙娥. 南平市人群血尿酸水平与非酒精性脂肪肝患病关系病例对照研究[J]. 中国公共卫生, 2021, 37(6): 1015-1018. doi: 10.11847/zgggws1125545
CHEN Bing-bing, LI Hui-quan, PAN Xin-ting, . Association between serum uric acid and non-alcoholic fatty liver disease risk among physical examinees: a case-control study[J]. Chinese Journal of Public Health, 2021, 37(6): 1015-1018. doi: 10.11847/zgggws1125545
Citation: CHEN Bing-bing, LI Hui-quan, PAN Xin-ting, . Association between serum uric acid and non-alcoholic fatty liver disease risk among physical examinees: a case-control study[J]. Chinese Journal of Public Health, 2021, 37(6): 1015-1018. doi: 10.11847/zgggws1125545

南平市人群血尿酸水平与非酒精性脂肪肝患病关系病例对照研究

doi: 10.11847/zgggws1125545
基金项目: 福建省自然科学基金(2019J01316)
详细信息
    作者简介:

    陈冰冰(1993 – ),女,福建泉州人,硕士在读,研究方向:慢性病流行病学

    通信作者:

    徐尚华,E-mail:13365998866@163.com

    彭仙娥,E-mail:fmuxe@163.com

  • 中图分类号: R 153

Association between serum uric acid and non-alcoholic fatty liver disease risk among physical examinees: a case-control study

  • 摘要:   目的  了解福建省南平市人群血尿酸水平与非酒精性脂肪肝(NAFLD)患病的关系,为NAFLD的预防控制提供参考依据。  方法  于2015年4月 — 2017年8月在南平市第一医院体检中心招募2 328名年龄18~70岁的健康体检者进行问卷调查、体格检查和实验室检测,参照《中国非酒精性脂肪性肝病诊疗指南》(2 010年修订版)中的影像学诊断标准将其中543例NAFLD患者和1 785名未患NAFLD体检者分别作为病例组和对照组,分析血尿酸水平与NAFLD患病的关系。  结果  病例组NAFLD患者血尿酸水平为(375.24 ± 93.36)μmol/L,高于对照组非NAFLD体检者血尿酸水平的(313.20 ± 76.59)μmol/L(t = – 15.664,P < 0.001);按血尿酸值水平进行四分位数分组,血尿酸水平最低四分位数、第二四分位数、第三四分位数和最高四分位数者NAFLD的患病率分别为8.34 %、23.52 %、22.51 %和43.13 %;在调整了性别、年龄、文化程度、职业、月平均收入、吸烟情况、饮酒情况、体育锻炼频率、慢性病病史、体质指数、收缩压、舒张压、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、谷丙转氨酶、天门冬氨酸氨基转移酶、谷氨酰转肽酶、肌酐、空腹血糖等混杂因素后,多因素非条件logistic回归分析结果显示,血尿酸水平第二四分位数和最高四分位数者NAFLD的患病风险分别为最低四分位数者的2.05倍(OR = 2.05,95 % CI = 1.35~3.11)和2.02倍(OR = 2.02,95 % CI = 1.29~3.17)。  结论  高血尿酸水平可增加南平市人群NAFLD的患病风险。
  • 表  1  2组人群一般情况计数资料比较

    项目病例组对照组χ2P
    例数%人数%
    性别 男性 371 68.32 735 41.18 123.044 < 0.001
    女性 172 31.68 1 050 58.82
    文化程度 小学及以下 42 7.74 129 7.22 22.260 < 0.001
    中学 227 41.80 559 31.32
    大专及以上 274 50.46 1 097 61.46
    职业 脑力劳动者 157 28.91 575 32.22 9.362 0.009
    体力劳动者 163 30.02 605 33.89
    其他 223 41.07 674 36.39
    月平均收入(元) < 2 000 33 6.08 111 6.22 1.096 0.578
    2 000~2 999 161 29.65 570 31.93
    ≥ 3 000 349 64.27 1 104 61.85
    吸烟情况 不吸烟 405 74.59 1 523 85.32 33.727 < 0.001
    吸烟 138 25.41 262 14.68
    饮酒情况 不饮酒 379 69.80 1 369 76.69 10.588 < 0.001
    饮酒 164 30.20 416 23.31
    体育锻炼频率(小时/周) ≤ 3 146 26.89 369 20.67 9.336 0.002
    > 3 397 73.11 1 416 79.33
    慢性病病史 305 56.17 1 548 86.72 239.313 < 0.001
    238 43.83 237 13.28
    下载: 导出CSV

    表  2  2组人群一般情况计量资料比较($\bar x \pm s$

    项目病例组对照组tP
    年龄(岁) 45.92 ± 11.53 41.14 ± 12.13 – 8.136 < 0.001
    体质指数(kg/m2 25.16 ± 2.75 21.88 ± 2.52 – 25.870 < 0.001
    收缩压(mm Hg) 124.57 ± 14.75 115.25 ± 14.29 – 13.211 < 0.001
    舒张压(mm Hg) 83.53 ± 10.01 77.42 ± 22.83 – 6.066 < 0.001
    甘油三酯(mmol/L) 2.11 ± 1.37 1.22 ± 0.77 – 19.245 < 0.001
    总胆固醇(mmol/L) 5.24 ± 0.95 5.00 ± 0.86 – 5.530 < 0.001
    高密度脂蛋白胆固醇(mmol/L) 1.20 ± 0.20 1.35 ± 0.34 9.353 < 0.001
    低密度脂蛋白胆固醇(mmol/L) 3.23 ± 0.86 3.14 ± 0.76 – 2.376 0.018
    谷丙转氨酶(IU/L) 31.72 ± 19.59 19.04 ± 13.51 – 17.084 < 0.001
    天门冬氨酸氨基转移酶(IU/L) 25.05 ± 9.16 21.42 ± 9.33 – 7.969 < 0.001
    谷氨酰转肽酶(IU/L) 38.23 ± 27.56 23.18 ± 18.45 – 14.670 < 0.001
    肌酐(mmol/L) 46.31 ± 2.45 46.10 ± 2.79 – 1.573 0.116
    空腹血糖(mmol/L) 5.68 ± 1.41 5.25 ± 1.06 – 7.632 < 0.001
    血尿酸(μmol/L) 375.24 ± 93.36 313.20 ± 76.59 – 15.664 < 0.001
      注:1 mm Hg = 0.133 kPa。
    下载: 导出CSV
  • [1] Nseir W, Hellou E, Assy N. Role of diet and lifestyle changes in nonalcoholic fatty liver disease[J]. World Journal of Gastroenter-ology, 2014, 20(28): 9338 – 9344.
    [2] Fazel Y, Koenig AB, Sayiner M, et al. Epidemiology and natural history of non-alcoholic fatty liver disease[J]. Metabolism, 2016, 65(8): 1017 – 1025. doi: 10.1016/j.metabol.2016.01.012
    [3] Wang FS, Fan JG, Zhang Z, et al. The global burden of liver disease: the major impact of China[J]. Hepatology, 2014, 60(6): 2099 – 2108. doi: 10.1002/hep.27406
    [4] Hediger MA, Johnson RJ, Miyazaki H, et al. Molecular physiology of urate transport[J]. Physiology, 2005, 20(2): 125 – 133. doi: 10.1152/physiol.00039.2004
    [5] Choi YJ, Shin HS, Choi HS, et al. Uric acid induces fat accumulation via generation of endoplasmic reticulum stress and SREBP-1c activation in hepatocytes[J]. Laboratory Investigation, 2014, 94(10): 1114 – 1125. doi: 10.1038/labinvest.2014.98
    [6] Lonardo A, Loria P, Leonardi F, et al. Fasting insulin and uric acid levels but not indices of iron metabolism are independent predictors of non-alcoholic fatty liver disease. A case-control study[J]. Digestive and Liver Disease, 2002, 34(3): 204 – 211. doi: 10.1016/S1590-8658(02)80194-3
    [7] Xie YL, Wang MJ, Zhang YJ, et al. Serum uric acid and non-alcoholic fatty liver disease in non-diabetic Chinese men[J]. PLoS One, 2013, 8(7): e67152. doi: 10.1371/journal.pone.0067152
    [8] 刘阳, 于世家, 文涛. 2型糖尿病合并非酒精性脂肪肝相关影响因素分析[J]. 中国公共卫生, 2018, 34(8): 1168 – 1170. doi: 10.11847/zgggws1119442
    [9] 中华医学会肝脏病学分会脂肪肝和酒精性肝病学组. 非酒精性脂肪性肝病诊疗指南[J]. 中国肝脏病杂志: 电子版, 2010, 2(4): 43 – 48.
    [10] 马冠生, 孔灵芝, 栾德春, 等. 中国居民吸烟行为的现状分析[J]. 中国慢性病预防与控制, 2005, 13(5): 195 – 199. doi: 10.3969/j.issn.1004-6194.2005.05.002
    [11] 马冠生, 朱丹红, 胡小琪, 等. 中国居民饮酒行为现况[J]. 营养学报, 2005(5): 16 – 19.
    [12] Zhou YJ, Wei FF, Fan Y. High serum uric acid and risk of nonalcoholic fatty liver disease: a systematic review and meta-analysis[J]. Clinical Biochemistry, 2016, 49(7/8): 636 – 642.
    [13] Wijarnpreecha K, Panjawatanan P, Lekuthai N, et al. Hyperuri-caemia and risk of nonalcoholic fatty liver disease: a meta-analysis[J]. Liver International, 2017, 37(6): 906 – 918. doi: 10.1111/liv.13329
    [14] Wang JH, Ma L, Chen SH, et al. Risk for the development of non-alcoholic fatty liver disease: a prospective study[J]. Journal of Gastroenterology and Hepatology, 2018, 33(8): 1518 – 1523. doi: 10.1111/jgh.14105
    [15] Zheng XY, Gong LL, Luo R, et al. Serum uric acid and non-alcoholic fatty liver disease in non-obesity Chinese adults[J]. Lipids in Health and Disease, 2017, 16(1): 202. doi: 10.1186/s12944-017-0531-5
    [16] Liu CQ, He CM, Chen N, et al. Serum uric acid is independently and linearly associated with risk of nonalcoholic fatty liver disease in obese Chinese adults[J]. Scientific Reports, 2016, 6(1): 38605. doi: 10.1038/srep38605
    [17] Yang C, Yang SJ, Feng CH, et al. Associations of hyperuricemia and obesity with remission of nonalcoholic fatty liver disease among Chinese men: a retrospective cohort study[J]. PLoS One, 2018, 13(2): e0192396. doi: 10.1371/journal.pone.0192396
    [18] Lombardi R, Pisano G, Fargion S. Role of serum uric acid and ferritin in the development and progression of NAFLD[J]. International Journal of Molecular Sciences, 2016, 17(4): 548. doi: 10.3390/ijms17040548
    [19] Li CG, Hsieh MC, Chang SJ. Metabolic syndrome, diabetes, and hyperuricemia[J]. Current Opinion in Rheumatology, 2013, 25(2): 210 – 216. doi: 10.1097/BOR.0b013e32835d951e
    [20] Zhu YZ, Hu YQ, Huang TL, et al. High uric acid directly inhibits insulin signalling and induces insulin resistance[J]. Biochemical and Biophysical Research Communications, 2014, 447(4): 707 – 714. doi: 10.1016/j.bbrc.2014.04.080
    [21] Vandanmagsar B, Youm YH, Ravussin A, et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance[J]. Nature Medicine, 2011, 17(2): 179 – 188. doi: 10.1038/nm.2279
    [22] 马志敏, 艾飞玲, 徐超楠, 等. 高尿酸血症与非酒精性脂肪肝关系研究进展[J]. 中国公共卫生, 2019, DOI: 10.11847/zgggws1123890.
    [23] Lanaspa MA, Sanchez-Lozada LG, Cicerchi C, et al. Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver[J]. PLoS One, 2012, 7(10): e47948. doi: 10.1371/journal.pone.0047948
    [24] Wan XY, Xu CF, Lin YM, et al. Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome-dependent mechanism[J]. Journal of Hepatology, 2016, 64(4): 925 – 932. doi: 10.1016/j.jhep.2015.11.022
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出版历程
  • 接收日期:  2019-08-12
  • 网络出版日期:  2020-06-24
  • 刊出日期:  2021-06-03

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