Abstract: For effective containment of coronavirus disease 2019 (COVID-19) epidemic, a multisectoral coordination mechanism was established and applied in emergency responses to three local and two major imported epidemics in Fujian province. The multisectoral coordination mechanism is characterized by the involvement of three departments (public health, public security, and industry and information technology) and comprehensive utilization of big data from the three departments. The application of the multisectoral coordination mechanism improved the efficiency of routine control measures and played an important role in successful coping with the COVID-19 epidemics in the province by adopting more active procedures instead of passive managements.