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2012 Vol. 28, No. 8

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Prevalence of dyslipidemia and its influencing factors in Kazakh adults
MA Ru-lin, GUO Shu-xia, LI Yan
2012, 28(8): 1009-1013. doi: 10.11847/zgggws2012-28-08-01
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Objective To assess the prevalence of lipid disorders and its related risk factors among Kazakh adults aged 18 years and older.Methods Stratified cluster sampling was adopted to select 3 935 Kazakh adults aged 18 years and older in Xinyuan country,Shihezi city and other regions for a questionnaire survey and physical examination.Fasting blood samples were collected for serum lipids detection.Descriptive epidemiological method and multivariate logistic regression analysis were used to analyze the prevalence of dyslipidemia and its risk factors.Results The total prevalence of dyslipidemia among the adults was 40.9%,with a standardized rate of 40.8%.The prevalence rates of hypertriglycerdemia,high total cholesterol(TC),high low-density lipoprotein cholesterol(LDC-c),and lowhigh-density lipoprotein cholesterol(HDL-c)were 19.4%,14.5%,7.7%,and 16.1%,with the standardized rates of 18.7%,12.6%,6.3%,and 18.5%,respectively.The prevalence of dyslipidemia in the males was 46.5%,higher than that of the females(37.2%,χ2=33.865; P=0.000).Multivariate logistic regression analyses showed that gender and body mass index(BMI)were risk factors of dyslipidemia(odds ratio[OR]=1.809,95% confidence interval[CI]:1.307-2.503; OR=1.835,95% CI=1.329-2.535).The amount of tea drinking,intakes of vegetables and fruits were protective factors for dyslipidemia(OR=0.588,95% CI:0.463-0.746; OR=0.591,95% CI:0.419-0.835).Conclusion The prevalence of dyslipidemia in Kazakh adults was higher than that of the national average,especially for high hypertriglyceridemia and lowHDL-c hyperlipidemia.The prevalence of dyslipidemia demonstrates an increase trend among the young adults.
Effects of deep sea fish oil supplimentation on rheumatoid arthritis patients
LI Lin, LI Yuan-hong, MA Wen-jun
2012, 28(8): 1013-1016. doi: 10.11847/zgggws2012-28-08-02
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Objective To study the effects of deep sea fish oil supplimentation on clinical manifestation and eryth rocyte sedimentation rate(ESR)among Chinese rheumatoid arthritis(RA)patients.Methods In a placebo-controlled,double-blind prospective study,60 RA patients were randomly allocated to consume a daily nutritional supplement of 6 gram oil capsules containing either soybean oil and deepsea fish oil(eicosapentaenoic acid[EPA]1.8 g+docosahexaenoic acid[DHA]1.2 g)for 12 weeks.Anthropometry and ESR were measured.Visual analogue scale(VAS),disease activity score(DAS),and health assessment questionnaire(HAQ)were used in the study.Results There were significant differences in intakes of polyunsaturated fatty acid(n-6 polyunsaturated fatty acid[n-6 PUFA ],n-3 PUFA,n-6/n-3[PUFA],linoleic acid[LA],linolenic acid[ALA],EPA and DHA)between the two groups(P < 0.01 for all).VAS(76.17±2.78)was significantly increased in fish oil group(t=-2.023,P=0.048),while DAS28(3.41±0.13,t=2.434)and ESR 17(7.50,52.00,Z=-2.012)were reduced(PDAS28=0.018,PESR=0.044).Conclusion Fish oil(1.8 g EPA+1.2 g DHA)/per day for 12 weeks)is beneficial to patients with RA.Dietary intervention maybe has long-term effects on RA patients.
Relationship between perceived stress and subjective well-being among middle school students
JIANG Hong, SONG Yu-mei, ZHANG Lan
2012, 28(8): 1017-1020. doi: 10.11847/zgggws2012-28-08-03
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Objective To examine the relationship between perceived stress and subjective well-being and to provide basis for promoting mental health among middle school students.Methods Questionnaires of subjective well-being and Perceived Stress Scale were used to survey 1 000 middle school students from 4 middle schools in Xinjiang Uygur Autonomous Region.Results The scores of girls were significantly higher than those of boys in perceived stress(t=11.28,P=0.001),but lower in subjective well-being(t=2.00,P=0.045),and there were differences in perceived stress and subjective well-being amomg the students of different grade(F=3.54,P=0.003; F=5.63,P=0.000).Perceived stress showed positive correlation with life satisfaction and interests(r=0.072,P < 0.05)and negative correlation with health concerns and relaxation of tension(r=-0.102,r=-0.112,P < 0.05).Foresee showed negative correlation with subjective well-being and all factors(except health concerns)(r=-0.559-0.374,P < 0.01).Control feeling showed negative correlation with health worry(r=-0.073,P < 0.05)and positive correlation with subjective well-being and all factors(r=0.161-0.291,P < 0.05).Overload showed positive correlation with subjective well-being and all factors(except health concerns)(r=0.174-0.293,P < 0.05).Perceived stress had obvious negative prediction to subjective welling(Beta=-0.184--0.673,t=-2.216--8.626,P < 0.05).Conclusion Perceived stress correlates closely with subjective well-being among Uygur middle school students.
Health status and its risk factors among workers with lowlevel benzene exposure
ZHANG Jing, LÜ Jian-ping, ZHANG Chen
2012, 28(8): 1020-1022. doi: 10.11847/zgggws2012-28-08-04
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Objective To examine health status of the workers with lowlevel benzene exposure and to explore its risk factors.Methods The health habit,clinical symptoms,and the decreased rate of white blood cell(WBC)were detected and compared among 823 health examinees(including 253 with direct benzene exposure,482 with indirect benzene exposure workers,and 88 without benzene exposure)using χ2 test.Risk factor analysis was conducted using logistic regression model.Results The workers with direct benzene exposure had a significantly higher rate of using personal protective equipment(78.3%)than those with indirect benzene exposuse(55.2%)(P < 0.05).Both workers with direct and inderect benzene exposure had a higher WBC fluctuation rate(32.2% and 40.7%)and a leukocytopenia rate(20.5% and 27.7%)than unexposed controls(6.8%,0%)(P <0.05).Benzene exposure,age,and the years with benzene exposuue were the risk factors of leukocytopenia.Conclusion Lowlevel benzene exposure could lead to hematotoxicity and leukocytopenia might be a susceptible predictor of hematotoxicity among the workers with benzene exposure.
Comparison of two-week morbidity and chronic disease morbidity among Kazakh herdsmen
RUI Dong-sheng, QIN Jiang-mei, Susanne Weigelin-Schwiedrzik
2012, 28(8): 1023-1026. doi: 10.11847/zgggws2012-28-08-05
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Objective To compare the changes of health status among Kazakh herdsmen in Xinyuan county of Xinjiang Uygur Autonomous Region before and after the NewRural Cooperative Medical Scheme(NCMS)implementation and to provide evidence for policy making and medical reform.Methods The data were from Health Service Survey conducted in the years of 2006 and 2008.The two-week morbidity and chronic diseases morbidity were analyzed with descriptive methods.Results The two-week morbidity rate incresased from 8.05%(2006)to 11.78%(2008),(χ2=21.02,P < 0.05).The chronic diseases morbidity increased from 15.97%(2006)to 24.27%(2008),(χ2=57.88,P < 0.05).Rheumatoid arthritis,hypertension,chronic gastroenteritis,gall-stone and cholecystitis,and anemia were the main diseases that Kazakh herdsmen suffered from.Conclusion Before and after the NCMS implementation,the health service needs of Kazakh herds men in Xinyuan county increased evidently.
Knowledge and practice about hypertension and its influence factors in rural residents
YANG Li, XU Xian-di, LIU Ya-tao
2012, 28(8): 1026-1030. doi: 10.11847/zgggws2012-28-08-06
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Objective To examine the status of hypertension-related knowledge and behavior among rural residents in middle and west areas of China and to analyze the influence factors and the relationship between the knowledge and behavior.Methods Cluster sampling was used to select rural residents from 84 villages of 16 counties in Gansu,Qinghai,Shanxi provinces and Xinjiang Uygur Autonomous Region and a face-to-face interviewwas carried out.Results Among 5 486 residents selected,the overall awareness rate of the hypertension-related knowledge was 31.13% and 54.46% of the respondents got the passing score.The rate of correct hypertension-related behaviors was 54.5%.The analytical results showed that with hypertension,with junior middle school education level or above,and having higher family income played a protective role on the awareness of hypertension-related knowledge.Being female,with hypertension,at age of between 25 to 40 years,and with better hypertension-related knowledge were protective factors of hypertension-related behaviors in the residents.Conclusion The awareness rate of hypertension-related knowledge of the rural residents needs to be improved and the related behavior also needs to be improved.The influence factors of the awareness rate of hypertension-related knowledge include nationality,education level,family income,and with or without hypertension.The influence factors of hypertension-related behaviors of rural residents include sex,nationality,age,whether with hypertension,and the awareness of hypertension-related knowledge.
HIV and syphilis infections among men who have sex with men
ZHOU Jian-bo, HAO Chao, HUAN Xi-ping
2012, 28(8): 1031-1035. doi: 10.11847/zgggws2012-28-08-07
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Objective To explore demographic characteristics,human immunodeficiency virus(HIV)high-risk behavior,and the prevalence and influencing factors of HIV and syphilis infections among men who have sex with men(MSM)in Changzhou city.Methods Questionnaire interviewwas conducted to collect information on demographic characteristics,behaviors of sex and drug use,HIV and sexually transmitted infections(STIs)related health services.Blood and urine samples were tested for HIV/syphilis antibodies and Neisseria gonorrhoeae(NG)and Chlamydia trachomatis(CT)infections.Results Of 593 participants,13.7%(81)were HIV-positive,31.2%(185) were sero-positive for syphilis infection,and 7.1%(42)were both HIV-positive and sero-positive for syphilis infection.There were 5.7%(34/592)of MSM having sexual abuse.In the latest 6 months,63.9%(379/592)of the MSM had anal sex with men,of which 24%(91/379)did not use condom in the recent anal sex.There were 47.2%(280/592)of the MSM having sex with women,of which 46.8%(131/280)did not use condom in the recent vaginal sex with women.Factors associated with HIV infection included age(χ2=14.83,P=0.005),occupation(χ2=11.06,P=0.047),sex abuse(odds ratio[OR]=2.97,95% confidence interval[CI]1.26-7.01),syphilis infection(OR=3.17,95% CI:1.88-5.35).The risk of HIV infection for student MSM was three times of that in workers/migrant workers(OR=3.01,95% CI:1.04-8.72).Factors associated with HIV infection included positive for HIV infection(OR=10.60,95% CI:1.09-103.55)and bleeding in sex abuse(OR=11.95,95% CI:1.27-112.68).Conclusion The HIV-high risk sex behavior was prevalent among MSM population in Changzhou city and the prevalence rates of HIV and syphilis infection were high.Screening of HIV and STIs and normative treatment to the diseases are essential in the high risk population.
Risk factors of gastric cardia cancer in rural area of southeastern Shanxi province: a case-control study
YANG Jian-zhou, JI Ai-fang, WEI Wu
2012, 28(8): 1035-1037. doi: 10.11847/zgggws2012-28-08-08
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Objective To explore the risk factors of gastric cardia cancer in rural area of southeastern Shanxi province.Methods A population based 1: 2 matched case-control study was conducted in rural area of southeastern Shanxi province.A total of 120 gastric cardia cancer patients and 240 matched controls were investigated with face-to-face questinnaire survey.The data were analyzed with conditional logistic model analysis.Results The family history of gastric cancer(odds ratio[OR]=2.83,95% confidence interval[CI]:1.74-2.94),cigarette smoking(OR=2.89,95% CI:1.57-5.30),and preference of taking hot food(OR=1.32,95% CI:1.12-2.79)significantly increased the risk of developing gastric cardia cancer,while body mass index≥24(OR=0.20,95% CI:0.06-0.67),drinking tea(OR=0.43,95% CI:0.15-0.78),and eating fresh fruits frequently(OR=0.62,95% CI:0.36-0.91)were protective factors.Conclusion Living and eating habits are risk factors of gastric cardia cancer in southeastern Shanxi province.The corresponding comprehensive prevention strategies targeting related risk factors are required.
Compliance of pre-exposure prophylaxis medication among Uighur HIV-negative spouses of HIV-positive individuals
ZHOU Hong-fang, SUN Yong, ZHAO Xiao-long
2012, 28(8): 1038-1041. doi: 10.11847/zgggws2012-28-08-09
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Objective To study the compliance of pre-exposure prophylaxis(PrEP)medication and its influencing factor among Uighur HIV-negative spouses of HIV-positive individuals and to provide clinical basis for the application of AIDS prevention drugs.Methods Intervention treatment was oral uptake of tenofovir(300mg)combined with emtricitabine(200mg).A total of 114 Uighur subjects were randomly divided into two groups and once-a-day and twice-a-weektreatment were given to each group for 7 months with a follow-up of every 4-week to knowthe compliance of the subjects.Results The compliance rate of PrEP reached 74.56%(85/114).Single-factor analysis revealed that the proportion of high HIV infective possibility in the compliance group and non-compliance group was 57.65%(49/85)and 13.79%(4/29),with a significant difference between the two groups(Z=-2.77,P < 0.001).The adherence rate of PrEP was 64.71%(55/85)and 27.59%(8/29)for compliance and non-compliance group when their spouse disagreed to the PrEP,and the possible adherence rate was 16.47%(14/85)and 27.59%(8/29)for the two groups,with a significant difference between the two groups(Z=-3.51,P < 0.001).Logistic regression analyses indicated that higher perceived infective possibility(odds ratio[OR]=4.59,95% confidence interval[CI]:1.46-14.36)and higher willingnes of adherence to PrEP when their spouse disagreeing PrEP(OR=3.78,95% CI:1.25-11.42)were factors for the improvement of PrEP medicine compliance.Conclusion PrEP medication promotion is applicable among HIV-negative spouses of HIV-positive individuals.The HIV-positive individuals'attitude to PrEP of their spouses and the risk of HIV-infection are major factors influencing medication compliance.
Occupational stress among primary and middle school teachers, wardens and video display terminal operators
NING Li, LIAN Yu-long, GE Hua
2012, 28(8): 1041-1043. doi: 10.11847/zgggws2012-28-08-10
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Objective To examine the occupational stress among primary and middle school teachers,wardens,and video display terminal(VDT)operators and to compare the stress levels among the occupational groups.Methods The participants were randomly sampled and surveyed with Job Stress Survey(JSS)questionnaire.Results For the 851 primary and middle school teachers,the intensity of occupational stress of the males(2.34±0.51)was higher than that of the females(2.19±0.59,P < 0.05)and the intensity of occupational pressure of the males(1.96±0.51)was higher than that of the females(1.85±0.55,P < 0.05).The insufficient organizational support was observed in the participants aged more than 40 years(1.78±0.54),which was higher than that of the others.Parteicipants with senior job title had higher occupational stress than those with lower job titles.The influence factors of job stress were age,sex,and education.For the 875 wardens,the intensity of occupational stress of the males(2.13±0.13)was higher than that of the females(2.10±0.15,P < 0.05).Participants with bachelor or higher education(2.14±0.55)had higher occupational stress than those with college or lower education(P < 0.05).The intensity of occupational pressure of the males(1.66±0.15)was higher than that of the females(1.63±0.18,P < 0.05).Insufficient organizational support was observed in the participants aged more than 40 years(1.67±0.17),which was lower than that of the other participants.The participants with senior job title had lower organizational support.The influence factors of job stress were sex and education.For the 842 video terminal operators,the intensity of occupational stress of the males(2.24±0.15)was higher than that of the females(2.10±0.13).The influencing factor of job stress was age.Conclusion For the occupational populations surveyed,the intensity of occupational stress of the male is higher than that of the females and the influence factors of job stress are gender and education for primary and middle school teachers and age is the influence factor among video display terminal operators.
Association between depression and social support among older adults in rural communities of Hubei province
BAI Tao, WU Li, JIANG Xue-jin
2012, 28(8): 1044-1048. doi: 10.11847/zgggws2012-28-08-11
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Objective To estimate the prevalence of depression in rural community elderly and to explore the association between social support and depression.Methods A cross-sectional study was carried out in three rural communities(17 villages)in Macheng city of Hubei province.Subjects aged 60 years or older were selected with cluster sampling.A structured questionnaire was used to investigate the prevalence of depression and relevant factors among the eldely.Results Totally 210(27.1%)males and 320(28.0%)females were identified as depression based on Geriatric Depression Scale(GDS),with a overall prevalence rate of 27.6%.After adjusting for potential confounding factors,requiring the subject's practical support to the family(odds ratio[OR]=0.36,95% confidence interval[CI]:0.25-0.51),giving required moral support to friends(OR=0.63,95% CI:0.43-0.92)were protective factors,while requiring subject's moral support to the family(OR=2.71,95% CI:1.75-4.19),giving required practical support to family(OR=1.82,95%CI:1.28-2.60)were risk factors of depression among the eldely.Conclusion High prevalence of elderly depression was boserved in the rural areas of Macheng city.Social support was an important influencing factor for elderly depression.
Effect of blueberry on HGF expression in rats with hepatic fibrosis
WANG Yu-ping, CHENG Ming-liang, GUAN Li
2012, 28(8): 1051-1054. doi: 10.11847/zgggws2012-28-08-12
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Objective To investigate the effects of blueberry on the prevention of liver fibrosis in rats and the influences of blueberry on hepatocyte growth factor(HGF),matrix metallopeptidase-9(MMP-9),and tissue inhibitor of metalloproteinase-2(TIMP-2)in liver tissues of the rats.Methods Sixty Wistar rats were divided into 6 groups(saline control group,model group,low,moderate,and high dose blueberry group,and Fuang Bie-Jia-Ruan-Gan tablet group).The hepatic fibrosis model of rat was established by intraperitoneal injection of porcine serum once daily for 12 weeks.The rats in blueberry treatment groups and Fu-Fang-Bie-Jia-Ruan-Gan tablet group were perfused with blueberry juice or FuFang-Bie-Jia-Ruan-Gan tablet for 12 weeks and the saline control group was treated with saline alone.All rats were sacrificed at the end of the treatments.Pathologic changes of hepatic tissue were evaluated with hematoxylin-eosin(HE)staining.Expressions of HGF,MMP-9,and TIMP-2 mRNA were detected with real-time fluorescent quantitative reverse transcriptise-PCR,and the expressions of HGF,MMP-9,and TIMP-2 protein in the liver tissue were detected by immunohistochemical assay.Results Compared with physiological saline control group,the mRNA and protein expressions of HGF,MMP-9,and TIMP-2 were significantly higher(P < 0.05 for all)in model group.The rats in moderate and high dose blueberry treatment groups showed significantly increased levels of HGF mRNA(634.9±61.2,637.7±68.2),HGF protein(31.8±3.0,31.2±4.3),MMP-9 mRNA(359.1±29.5,361.4±27.1),MMP-9 protein(39.4±4.0,38.5±3.7)and decreased levels of TIMP-2 mRNA(426.0±16.7,431.3±33.0),TIMP-protein(41.6±6.2,37.3±4.3),respectively,compared to those of model group.Conclusion Blueberry has preventive effect on porcine serum-induced liver fibrosis in rats.The mechanism may be associated with the up-regulated expressions of HGF and MMP-9 and down-regulated expression of TIMP-2.
Impacts of hyperthemia and scald on hepatorenal function in rabbits
SUN Jun-feng, LIU Shang-ji, ZHAN Jian-hua
2012, 28(8): 1054-1056. doi: 10.11847/zgggws2012-28-08-13
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Objective To observe early changes of hepatorenal function and the changes of visceral pathology after hyperthermia and scald in rabbits.Methods The rabbits were randomly divided into normal environment group,hyperthermia group,and heat acclimatization group and reared in the environment with different temperature and exposed to scald.Alanine aminotransferase(ALT),creatinine(Cr)were dynamically detected and pathomorphologic changes of liver and kidney 2 days after scald exposure were compared for the rabbits.Results There was no death in normal environment group; one rabbit dead in heat acclimatization group and 3 rabbits dead in hyperthermia group.ALT(69.3±1.5 U/L)and Cr(72.0±6.5 umol/L)of the rabbits in heat acclimatization group were obviously higher than those of normal environment group(43.3±4.5 U/L and 61.0±3.6 umol/L)and hyperthermia group(46.3±7.6 U/L and 61.3±3.6 umol/L; P < 0.05).ALT,Cr of the rabbits in hyperthermia group and heat acclimatization group were obviously higher than those of normal environment group after burn.ALT(167.0±24.9 U/L)and Cr(211.5±7.2 μmol/L)of the rabbits in hyperthermia group were obviously higher than those of heat acclimatization group(136.0±7.0 U/L and 155.3±2.2 μmol/L; P < 0.05)after burn exposure.The liver and kidney were injured most seriously in hyperthermia group.ConclusionThe combined effects of hyperthermia and burn are far stronger than burn and heat acclimatization might be beneficial to relieve the combined effects in scalded rabbits under hyperthermia environment.
DEHP mediated by peroxisome proliferator-receptors affect functions of ovary of female mice
ZHANG Yu-min, MA Ming-yue, PEI Xiu-cong
2012, 28(8): 1057-1059. doi: 10.11847/zgggws2012-28-08-14
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Objective To assess the effects of di-2-ethylhexyl phthalate(DEHP)on female reproductive system in mice mediated through peroxisome proliferator-receptors(PPARs).Methods Fourty female ICR mice of 21 days were randomly divided into 0,20,100,and 500 mg/kg dose group.With continuous DEHP exposure for 10 days and 24 hours after cessation of the exposure,the mice were killed.PPARs mRNA expression levels were determined by real time-PCR.Estradiol and progesterone levels in serum were detected with enzyme-linked immunosorbent assay(ELISA).Results The ovarian wet weight and organ coefficient decreased significantly in 100 and 500 mg/kg DEHP exposure groups compared with those of the control group(P < 0.05).Serum estradiol level in 500 mg/kg DEHP group decreased significantly compared with the control group(P < 0.05).Compared with that of the control group,progesterone level showed a significant difference(P > 0.05).The PPARα,PPARβ mRNA expression levels in DEHP exposure groups were not significant different from those of the control group(P > 0.05).PPARγ mRNA expression level increased significantly in DEHP expouse groups compared with the control group(P < 0.05).Conclusion As a peroxisome proliferator mediating PPARs gene expression,DEHP could affect ovarian function in mice.
Protective effects of magnesium sulfate on renal ischemia-reperfusion injury in mice
LI Zu-cheng, LI Shu-cui, KANG Ze-chun
2012, 28(8): 1059-1061. doi: 10.11847/zgggws2012-28-08-15
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Objective To investigate whether magnesium sulfate could protect kidney against ischemia/reperfusion(I/R)injury.Methods Kunming male mice were randomly divided into sham group and model group and treated with magnesium sulfate(120 mg/kg and 60 mg/kg).I/R were induced by occlusion of left renal pedicle for 45 minutes followed by a three hours of reperfusion except sham group.After the reperfusion,the blood samples were collected and blood urea nitrogen(BUN)and serum creatinine were measured for the evaluation of renal function.The content of malondialdehyde(MDA),superoxide dismutase(SOD)activity,and glutathione peroxidase(GSH-Px)activity in left kidney tissues were detected,and histological examination was carried out.Results Compared with the model group,renal dysfunction of the mice treated with magnesium sulfate was improved; the content of MDA in the kidney tissues was decreased and the activities of SOD and GSH-Px were increased.The changes in the biochemical parameters were associated with histological change of the kidneys,particularly in the high-dose magnesium sulfate group.Conclusion The findings suggest that magnesium sulfate has renal-protective effects on renal I/R injury in mice,which is probably related to inhibition of lipid peroxidation.
Antifungal effect of seven terpenes against Aspergillus flavus
LIANG Hai-yan, WANG Guo-chang
2012, 28(8): 1062-1064. doi: 10.11847/zgggws2012-28-08-16
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Objective To evaluate antifungal effects of 7 terpenes against Aspergillus flavus(A.flavus)and to provide basis for development of antimicrobial against A.flavus.Methods The anti-A.flavus effects of the terpenes were investigated at the concentrations of 1 μL,2 μL,4 μL,and 8 μL with gaseous diffusion methods.Results All treatments had inhibitory effect on hyphal growth,with the exception of 1 μL farnesen,1 μL β-ocimene,and 1 μL α-pinene.Myrcene at the concentrations of 1 μL,2 μL and 4 μL,β-ocimene at 1 μL,and terpinene at 1 μL were lack of inhibition on spore germination.The terpenes at other concentrations could inhibit spore germination significantly.The antifungal effect of linalool was the strongest with an inhibitory rates on hyphal growth and spore germination of 76.53% and 86.32% at the concentration of 8 μl/L.Conclusion The results indicate that the seven terpenes could inhibit A.flavus at different extent,and the effects of linalool is the best.
Protective effects of tert-butylhydroquinone on NaAsO2-induced cytotoxicity in HaCaT cells
XING Xiao-yue, LI Bing, LI Wei
2012, 28(8): 1065-1067. doi: 10.11847/zgggws2012-28-08-17
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Objective To study protective effect of tert-butylhydroquinone in HaCaT cells on the damage induced by NaAsO2 in vitro.Methods Alamar Blue reduction rate was used to evaluate cell vitality.The level of reactive oxygen species(ROS)was detected by staining cells with 2',7'-dichlorofluorescin diacetate(DCFH-DA).The melondiadehyde(MDA)level was measured by thiobarbituric acid(TBA)method.Results The viability of HaCaT cells was decreased by 82% and 59% after exposed to NaAsO2 at the concentrations of 25 μmol/L and 50 μmol/L but the viability was 92% and 91% for the two exposure groups pretreated wtih tert-butylhydorquinone(tBHQ).Comparted to the control groups,the level of ROS increased by 1.64 and 3.86 times in the HaCaT cells exposed to 25 μmol/L and 50 μmol/L NaAsO2 but only by 0.95 and 1.87 times for the same exposure groups pretreated with 25 μmol/L tBHQ and by 0.79 and 1.69 times for the two groups pretreated with 50 μmol/L tBHQ.The MDA levels increased significantly in HaCaT cells exposed to NaAsO2(2.28 mol/L/mg·prot for 25 μmol/L NaAsO2 exposure,2.96 mol/L/mg·prot for 50 μmol/LNaAsO2 exposure; P < 0.01)and the increased levels of MDA were 2.05 μmol/L/mg·prot and 2.43 mol/L/mg·prot for 25 μmol/L pretreatment of tBHQ and 2.10 nmol/mg · prot and 260 nmol/mg · prot for 50 μmol/L/L tBHQ pretreatment groups.Conclusion tBHQ could protect HaCaT cells from damage induced by NaAsO2 in a dose-reaction manner.
Genotypes associated with virulence in environmental isolates of O1/O139 Vibrio cholerae in Guangdong province
LI Bai-sheng, TAN Hai-ling, DENG Xiao-ling
2012, 28(8): 1067-1069. doi: 10.11847/zgggws2012-28-08-18
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Objective To analyze the virulence genes and genotyping characteristics of environmental O1/O139 Vibrio cholerae(V.cholerae)in Guangdong province and to provide the basis for the prevention and control of cholera.Methods Eight pairs of primers were designed according to ctxA,ace,zot,tcpA,tcpI,hlyA,ompU,and toxR.The multi-plex PCR(MPCR)was established to detect 90 V.cholerae O1/O139 strains isolated between 2008 and 2009(69 aquatic strains,16 sea food strains and 5 clinical strains).Genotypes associated with the virulence were determined then accord-ing to the result of the MPCR.Results The hlyA and toxR genes were positive in all the isolates.Three of five clinical isolates were detected for eight virulence genes and the other two isolates displayed the genotype of virulence with toxR+,ompU+,zot+,tcpA+,tcpI+,hlyA+,toxR+,and tcpA+.For the aquatic isolates,14 Inaba strains(34.15%,14/41)were hlyA+,toxR+,ompU+,ace+,zot+,tcpI+,while 12 Ogawa strains(66.67%,12/18)and 7 O139 strains(70%,7/10)were hlyA+and toxR+.For sea-food isolates,3 Inaba strains(75%,3/4)were hlyA+,toxR+,ompU+,and tcpI+; while the Ogawa strains presented different genotypes.Conclusion The environmental O1/O139 Vibrio cholerae in Guangdong province display widespread non-toxigenic strains with virulence genotype diversity.
Prevalence of occupational exposure to blood-borne substance and its influencing factors among medical practice students
YUAN Su-mei, BAO Yan-ping, REN Ji-lian
2012, 28(8): 1070-1073. doi: 10.11847/zgggws2012-28-08-19
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Objective To study the prevalence of occupational exposure to blood-borne substance and its influencing factors among medical practice students.Methods A stratified cluster sampling was used to conduct a questionnaire survey among 510 graduates from a medical college.The data were analyzed with SAS 9.1 software.Results During the one-year practice,27.70% of the students had experienced occupational exposure to blood-borne substance.Exposure due to splashing into mucosa,sharp injuries,and contaminating wound accounted for 31.19%,66.06%,and 2.75% for all exposures,respectively.For the exposure events,68.93% were registered and 84.47% were treated immediately.The results of analyses showed education background,profession,the knowledge of protection,and the situation of training were correlated with the rates of exposure(P < 0.05).Logistic regression analyses showed that the involement in nursing or laboratory work and without the knowledge of howto deal with the contaminated sharp waste were the independent risk factors for the exposure.Compared with clinical profession,the risks of nursing and laboratory profession increased by 64% and 287%,respectively.The exposure risk for the students who did not knowhowto deal with the contaminated sharp waste was 1.64 times higher than that of whom knewthe knowledge.Conclusion The practice students are at a high risk of occupational exposure to blood-borne substance.The students majored in laboratory and nursing,and who did not knowhowto deal with the contaminated sharp waste are prone to the exposure.
AIDS related knowledge and risk behavoirs among newtype drug abusers
WANG Wei, REN Gui-qiu, ZHAO Heng-wei
2012, 28(8): 1073-1075. doi: 10.11847/zgggws2012-28-08-20
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Objective To investigate the knowledge about human mmunodeficiency virus/acquired immunodeficiency syndrome(HIV/AIDS)and high risk sexual behaviors among newtype drug abusers.Methods Totally 247 newtype drug abusers recruited from nine compulsory isolation detoxification centers in Liaoning province from January 2009 to December 2010 were surveyed with a questionnaire.Logistic regression analysis was used to analyze the influential factors of high risk sexual behavior among the newtype drug abusers.Results The average awareness rate of HIV/AIDS knowledge was 61.9%(153/247); the rates of non-condom use in sexual behavior and multiple sexual partners were 65.4%(140/247)and 76.5%(189/247),respectively.Multiple regression results showed that male(odds ratio[OR]=3.20,95% confidence interval[CI]:1.34-7.63)and positive attitude to condom use(OR=3.47,95% CI:1.39-8.70)were the risk factors of high risk sexual behaviors among the newdrug abusers,whereas high AIDS knowledge score was a protective factor.Conclusion The newdrug abusers of male and with lowAIDS knowledge score and negative attitude toward condom use are more likely to have high risk sexual behaviors.
Effect of job pressure on mental health and its machanism among primary and secondary school principals
ZHANG Xiang
2012, 28(8): 1076-1078. doi: 10.11847/zgggws2012-28-08-21
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Objective To explore the relationship between job pressure,social support,and coping style and mental health among primary and secondary school principals.Methods A total of 180 school principals were selected with cluster sampling from a principal training class in Guizhou province.The participants were surveyed with Principal Job Pressure Questionnaire,Social Support Rating Scale(SSRS),Simplified Coping Style Questionnaire(SCSQ),and SelfRated Health Measurement Scale(SRHMS).A path analysis was carried out by AMOS version 6.0.Results The job pressure in the principals was at moderate level and the average score of overall job pressure was 3.14±0.96(theoretical range of 1-5),in which the maximum was entrance exam pressure(3.03±1.00)and the minimum was relationship pressure(1.99±0.89).The mental health of the principals was at moderate and upper level and the average score of mental health was 84.29±14.28(theoretical range of 1-120).Job pressure,social support,subjective support,and positive coping were significantly related to mental health(P < 0.05).The structural equation model showed that the job pressure had both direct and indirect effects on mental health with the mediation effect of subjective support and indirect effect of positive coping.Conclusion The subjective support and positive coping have mediation effect on the relationship between job pressure and mental health in primary and middle shcool principals.
Awareness of and satisfaction with newrural cooperative medical care among farmers
BAI Li, LIU Ji-cheng, CUI Guang-cheng
2012, 28(8): 1079-1081. doi: 10.11847/zgggws2012-28-08-22
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Objective To evaluate the awareness of and satisfaction with newrural cooperative medical care system in the farmers in Heilongjiang province and to provide the basis for the improvement of newrural cooperative medical care system.Methods Home visit was conducted among farmers selected with random sampling and χ2 test and factor analysis were adopted to analyze the data.Results There was a significance in cognition of newrural cooperative medical care system(χ2=23 339.172,P=0.000)and the overall satisfaction with the system was 62.767%.The expected proportion of compensation was significantly different among different farmers(χ2=136.700,P=0.000).Conclusion The awareness of and the satisfaction with the newrural cooperative medical care system are lowamong rural residents of Heilongjiang province.The proportion of compensation,the payment of the residents,and the government investment should be increased.
Genotyping of clinic of Mycobacterium tuberculosis isolates by multilocus variable number of tandem repeat analysis(MLVA)
WEN Jian-qiang, TIAN Wei-hua, LIU Zhi-guang
2012, 28(8): 1081-1083. doi: 10.11847/zgggws2012-28-08-23
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Objective To genotype clinic Mycobacterium tuberculosis isolates with multilocus variable number tandem repeat analysis(MLVA)and to provide scientific basis for prevention and control of tuberculosis.Methods Totally 15 variable number tandem repeats(VNTR)loci were analyzed with PCR and agarose gel electrophoresis.The gene diversity was analyzed with BioNumerics 3.0 software.Results A total of 127 different allele profiles(including 90 unique patterns)were identified by 15 VNTR loci for all 215 isolates of 7 clusters.For all isolates 74.88%(161/215)were dominant in Gansu province.Univariate analysis showed that the clustered strains were not significantly associated with the resistance to all of four drugs(rifampin,isonicotinyl hydrazide,ethambutol,and streptomycin),patient's gender,age,regular on irregular therapy,and newcases or relapses(P > 0.05 for all),while significantly associated with antituberculosis therapy history(P >0.05).Conclusion The strains of Mycobacterium tuberculosis isolated in Gansu province present definitely gene diversity.
Knowledge and behavior about rabies prevention among children in Zhao-qing municipality
HUANG Guo-hua, ZHOU Yue-hua, XIE Hai-bin
2012, 28(8): 1084-1086. doi: 10.11847/zgggws2012-28-08-24
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Objective To examine the risk behavior,post-exposure disposal,knowledge,attitude and knowledge sources related with rabies among children in Zhaoqing city and to provide basis for health education and intervention programs.Methods Stratified random sampling at city,county,township,and village-level was used to recruit 1 251 children from 6 primary schools in May 2008.Face-to-face interviews were used to collect information.Data were entered using Epidata and analyzed with SPSS.Results The history of exposure was different among the children in different districts(P < 0.01).The proportion of exposure was highest among children in villages(11.25%).The risk behaviors were more common and the time of playing with dogs and cats were longer among the childen in villages and townships compared to the children in the county or in the city.After bitten or scratched by dog or cat,many children went to visit a doctor or inform their caregivers.The children in the city had more knowledge about rabies than children in county or village(P < 0.01).The most common sources for knowledge on rabies was teachers,television and the family.Conclusion The exposures of dog bite or cat scratch were more common among children in countryside than those in urban areas.The knowledge on rabies were lower among children in countryside than those in urban areas.The health education programs should be targeted in countryside and the contents should focus on risk behaviors,the definition of exposure,and post-exposure disposal.
Psychological health condition and its influence factors among freshmen with suicidal ideation
WANG Bing-wei
2012, 28(8): 1086-1088. doi: 10.11847/zgggws2012-28-08-25
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Objective To examine the suicidal ideation and its psychological factors among freshman for making related preventive strategies.Methods Totally 3 850 freshmen from Henan Institute of Science and Technology were investigated with University Personality Inventory(UPI),Symptom Checklist 90(SCL-90).Psychological factors associated with suicidal ideation were analyzed with binary logistic regression.Results The positive ratio of the suicidal ideation was 4.21%.There was a significant difference in the suicidal ideation between the students with different education background(χ2=12.36,P=0.000)and different majors(χ2=18.4,P=0.002).There was no significant difference between female and male(χ2=0.299,P=0.583).The scores of UPI and SCL-90 showed that the students who had suicidal ideation had higher total score and the scores of ten factors than normal students(P < 0.01).The logistic regression results indicated that the factors obviously correlatd with suicidal ideation were depression(odds ratio[OR]=17.238),additional items(OR=2.453),hostility(OR=1.713),paranoid(OR=1.647),gender(OR=0.676),interpersonal-sensitivity(OR=0.449),and obsessive-compulsive(OR=0.412).Conclusion The mental health level of the freshmen with suicidal ideation is low.The depressed mood,sleeping disturbances,hostility,and paranoid are the risk factors of suicidal ideation.More attention should be taken to promote the mental health of the freshmen.
Analysis on current situation and correlated behavior of hepatitis C virus infection among drug users in Gansu province
LI Jian, MENG Lei, YU Ai-ling
2012, 28(8): 1089-1090. doi: 10.11847/zgggws2012-28-08-26
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Objective To explore current situation and correlated factors of hepatitis C virus(HCV)infection among drug users in Gansu province.Methods SPSS 13.0 was used in a comparative analysis between HCV positive cases and HCV negative cases among 2 464 drug users in Gansu province.Results HCV positive rate was 10.6%(246/2 327)in the drug users.Among the HCV positive cases and HCV negative cases,the ratio of injection drug user was 47.5%(124/261),10.3%(226/2 203); the ratio of needle sharing was 27.4%(34/124)and 20.8%(47/226); the ratio of non-commercial sexual behavior without using condom was 66.2%(88/133)and 46.8%(645/1 377); and the ratio the commercial sexual behavior without condom use was 35%(14/40)and 16.8%(82/489),respectively.Conclusion Needle sharing and unsafe sexual behavior are the important factors for HCV infection and transmission of HCV among drug users in Gansu province.
Health knowledge and behavior among rural residents after a heavy debris flowin Zhouqu county, Gansu province
QIAN Guo-hong, ZHU Ze-shan, JIN Ying
2012, 28(8): 1091-1092. doi: 10.11847/zgggws2012-28-08-27
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Objective To explore health knowledge and health behaviors among rural residents after a heavy debris flowand to provide scientific basis for post-disaster health education and intervention strategies.Methods A totol of 1 120 residents aged 15 to 69 years from different villages of Zhouqu county were randomly selected.General conditions,health knowledge and awareness rate,health behavior formation rate,and ways of accessing to health knowledge were investigated with a questionnaire survey.Data were analysed with SPSS 3.0.Results The awareness rate of health knowledge in the residents was 71.64%(827/1 100),in which the awareness rate of washing hands before cook was the highest(91.82%,1 010/1 100).There were 12.00%(132/1 100)of the residents dinking water directly from river or well and 39.00%(429/1100)visiting a doctor when having the symptoms of diarrhea or fever,and 19.00%(209/1 100)not uisiting a psychological doctor when having psychological problems.Totally 59.1%(650/1 100)of the residents got the knowledge of disease prevention after the disaster and 52.45%(577/1 100)acquired disease prevention knowledge through reading posters and issued leaflets,27.64%(304/1100)through listening to explanation of health workers.Conclusion The demand of disease prevention knowledge among the residents in the disaster areas was higher than that before the disaster and the propaganda and education of health and disease prevention should be implemented in time.
Analysis on human resource for laboratory in institutions of disease control and prevention in Shandong province, 2007-2009
SUN Qi-hua, ZHANG Ying-jie, KANG Dian-min
2012, 28(8): 1093-1096. doi: 10.11847/zgggws2012-28-08-28
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Objective To examine the change trend of human resource for laboratory in institutions of disease control and prevention in Shandong province during 2007-2009 and to provide evidence for making human resource plan.Methods A self-designed questionnaire was used to survey all laboratory staff in centers for disease control and prevetion(CDCs)in Shandong province from 2007 to 2009.Results In general,the number and the proportion of laboratory staff were the highest in 2008.The proportion of the staff over the age of 50 years was declined and that of under the age of 40 years was increased.The proportion of the staff with the education under junior college declined and that of with undergraduate or higher education increased from 33.70%(555/1647)to 42.43%(695/1638).The proportion of the staff with senior professional title increased and that of with intermediate title declined year by year.The professional structure of the staff at different administrative levels differed greatly.Conclusion During the three years,the laboratory staff in CDCs in Shandong province were optimized in total number,age distribution,and education level,but there were still some shortcomings as the quantity,title structure and the professional structure should be improved.
Prevalence and influeace factors of anxiety and depression among scientific personnel
LEI Xiu-wen, YUAN Ye-feng, LIAO Ping
2012, 28(8): 1096-1098. doi: 10.11847/zgggws2012-28-08-29
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Objective To explore prevalences and influence factors of anxiety and depression among scientific personnel and to provide reference for psychologitic intervention.Methods A self-administered questionnaire on general condition,Self-Rating Anxiety Scale(SAS),and Self-Rating Depression Scale(SDS)were used to assess 252 scientific personnel.Results The prevalece of anxiety was 20.23% without gender difference(28.13% for males and 22.87% for females)(χ2=0.818,P=0.366).The prevalence of depression was 22.22% without gender difference(30.89% for males and 25.11% for females)(χ2=0.115,P=0.735).The years of working,living condition,and economic pressure had positive correlation with anxiety.Age had a positive correlation with depression.The self reported month income,interpersonal relationship,and the fulfillment of family responsibility had negative correlation with anxiety and depression.Conclusion Scientific personnel have obvious anxiety and depression problems which are affected by various psychological factors.Specific health promotion should be conducted among the personnel.
Cryptosporidium infection among HIV/AIDS patients with chronic diarrhea in Beijing
LI Min, LIU Ying, WANG Hui-zhu
2012, 28(8): 1099-1101. doi: 10.11847/zgggws2012-28-08-30
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Objective To investigate the infection of Cryptosporidium and other pathogenic germs among HIV/AIDS patients with chronic diarrhea.Methods Stool samples were collected from confirmed HIV/AIDS patients with chronic diarrhea and living in Beijing.The samples were concentrated by formalin-ethyl acetate sedimentation technique and stained by modified acid-fast stain for the identification of oocysts by microscopy.And nest-PCR was adopted.CD4+count was detected by flowcytometry.Results The infection rate of Cryptosporidium in the patients was 5.97%(4/67).The bacterial culture detected 60 cases of fungus infection and one case was positive for Clostridium difficile toxin.Conclusion AIDS patients infected by Cryptesporidium are not rare in Beijing,and the infectious rate is not associated with patient's gender but associated with patient's living environment,especailly for the patients living in the countrysides and with lower level of CD4 cells and the patiens in the middle-late period of the disease.
Cost-effectiveness analysis of different intervention about AIDS prevention in coal mine peasant workers
JIANG Shao-zhen, GAO Yong-ming, YU Qing
2012, 28(8): 1101-1103. doi: 10.11847/zgggws2012-28-08-31
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Objective To evaluate cost-effectiveness of different interventions on AIDS in coal mine peasant workers.Methods From July to December,2009,459 peasant workers were selected in a coal mine of Kailuan Mine Group and divided into three groups.After a base line investigation,the interventions including distribution of propaganda materials,special lectures,and peer education were carried out for six times in five months.Then the in formation on AIDS-related sexual risk behavior and condom usage were collected.Cost-effect ratio was applied to evaluate the effect of each intervention.Results Five months after the intervention,the rate of condom use in commercial sex behavionir for the group of receiving propaganda materials was increased from 50.7% to 55.2%(χ2=0.683,P=0.408); the rate of condom use in the group receiving special lectures was increased from 51.0% to 78.0%(χ2=23.342,P=0.000)and for the group of peer education the rate was increased from 44.6% to 66.7%(χ2=15.920,P=0.000).The cost for the prevention of one case human immunodeficiency virus infection in the group of receiving propaganda materials,the group of receiving special lectures,and the group of peer education was 48 214.29,41 195.65,and 55 138.89 yuan RMB,respectively.Conclusion For the cost-effectiveness point of view,special lectures is the best intervention measure in coal mine peasant workers for prevention of AIDS.
2012, 28(8): 1106-1107. doi: 10.11847/zgggws2012-28-08-33
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2012, 28(8): 1108-1111. doi: 10.11847/zgggws2012-28-08-34
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2012, 28(8): 1111-1112. doi: 10.11847/zgggws2012-28-08-35
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2012, 28(8): 1113-1117. doi: 10.11847/zgggws2012-28-08-36
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2012, 28(8): 1117-1120. doi: 10.11847/zgggws2012-28-08-37
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Evaluation on effects of HB vaccine inoculation and health education among undergraduates of Gansu province
GAO Li, WU Xiao-ping, WANG Ping-gui
2012, 28(8): 1121-1123. doi: 10.11847/zgggws2012-28-08-38
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Objective To evaluate the effects of hepatitis B(HB)vaccine inoculation and health education in undergraduates of Gansu province.Methods Questionnaire surveys on awareness rate and attitude about hepatitis B and the immunization coverage rate of HB vaccine were conducted before and after implementation of the projects in Gansu province.Multiple stratified cluster sampling method was used in the survey.Results After the implementation of the projects,the HB virus vaccine full-course coverage rate among the students was improved from 27.95% to 97.14% compared with the baseline survey.The awareness rate of undergraduates about transmission way of hepatitis B was improved from 31.35% to 68.18%(P < 0.001).The awareness rate about other hepatitis B knowledge was increased from 63.92%-85.05% to 84.32%-90.73%(P < 0.001).The number of the undergraduates who thought hepatitis B being a serious illness was increased from 74.77% to 88.42%.The ratio of students trying to avoid contacting with HB virus carriers was decreased from 8.69% to 1.82%.And the ratio of students not minding eating together with HB virus carrier was increased from 29.27% to 64.57%(P < 0.001).Conclusion Through implementation the project,the awareness of undergraduates about hepatitis B is obviously improved and the discrimination against HB virus carrier in the undergraduates decreased.The HB virus vaccines full-course coverage rates among the students are significantly increased.
Effects of cognitive psychotherapy on coping style and self-efficacy in patients with acute leukemia under chemotherapy
LI Xiao-yun, ZHANG Jing-ping, PENG Fang
2012, 28(8): 1124-1126. doi: 10.11847/zgggws2012-28-08-39
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Objective To investigate the coping style and self-efficacy in patients with acute leukemia under chemotherapy and to evaluate the effects of cognitive psychotherapy.Methods Eighty two patients with acute leukemia under chemotherapy were recruited and assigned into routine nursing group and cognitive psychotherapy group.All the patients were evaluated with Medical Coping Modes Questionnaire(MCMQ),General Self-Efficacy Scale(GSES)before and after the intervention.Results The scores of avoidance(16.98±2.83)and resignation(10.76±2.83)of MCMQ of the patients were higher than those of the norm with a significant difference(P=0.000).The score of confrontation of the patients(19.38±3.67)was similar to that of the norm.The general self-efficacy score(2.52±0.59)of the patients was lower than that of the norm with a significant difference(P=0.000).Compared with the control group,the scores of confrontation and self-efficacy were significantly improved in the experimental group,while the scores of avoidance and resignation were significantly decreased(P < 0.05).Conclusion Avoidance and resignation are the coping styles most frequently used by the patients with acute leukemia under chemotherapy and their self-efficacy level was low.Cognitive psychotherapy is proved to be effective to promote the patients using more positive coping styles and improving self-efficacy.
2012, 28(8): 1126-1127. doi: 10.11847/zgggws2012-28-08-40
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Continuous monitoring of clinical distribution and drug resistance of Proteus mirabilis
NIAN Hua, CHU Yun-zhuo, Tian Su-fei
2012, 28(8): 1130-1132. doi: 10.11847/zgggws2012-28-08-42
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Objective To assess the variations of clinical distribution and drug resistance of Proteus mirabilis and to provide reference for clinical selection of antibiotics.Methods The bacteria were identified by VITEK-2 and PHEONIX system.Antibiotic sensitivity test was conducted with Kirby-Bauer method and automatic machine.The data were analyzed by WHONET 5.4 software.Results There were 844 isolates of Proteus mirabilis during the 10 year's monitoring,with 304 from urine(36.0%),263 from sputum(31.2%),and 176 from secretion(20.9%).The rate of extended-spectrum β-lactamases(ESBLs)production was 45.6%,57.0%,and 37.2% for the isolates in 2008,2009,and 2010,respectively.The drug resistance rate of Proteus mirabilis to cephalosporin increased with the time and the rate to carbapenem was 3.0%.The resistance rate to quinolones obviously increased after 2005.Conclusion The drug resistance rate to quinolones and cephalosporin increased in recent years but carbapenem and enzymeinhibitor still maintain well antimicrobial activity to Proteus mirabilis.
2012, 28(8): 1133-1133. doi: 10.11847/zgggws2012-28-08-43
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Relationship between calciotropic hormone levels and gene polymorphisms of estrogen receptor and vitamin D receptor among children
HOU Jia-xiang, LI An-qi, LUO Yi-xin
2012, 28(8): 1148-1150. doi: 10.11847/zgggws2012-28-08-46
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Objective To explore the relationship between calciotropic hormone levels and gene polymorphisms of estrogen receptor(ER)and vitamin D receptor among children.Methods Totally 140 healthy Chinese children aged 8-12 years living in Henan province were recruited.Polymerase chain reaction-restricted fragment length polymorphisms(PCR-RFLP)method was used to detect PvuⅡ and XbaⅠ polymorphisms of ERα gene and FokⅠ polymorphism of vitamin D receptor(VDR)gene.Calcitonin(CT)and osteocalcin(OC)levels in serum were measured using radioimmunoassay.Results Serum OC concentration of the children with different genotypes of ER PvuⅡ were 5.82 μg/L for PP,5.01 μg/L for Pp,and 6.21 μg/L for pp.Serum OC concentration of the children with pp genotype was significantly higher than those with PP and Pp genotypes(P < 0.05).However,the differences between serum Ca and serum CT were not observed in different ER PvuⅡ genotypes(P > 0.05 for all).There were no significant differences in serum CT and OC concentrations among children carrying different FokⅠ genotypes of VDR gene(P > 0.05).Serum Ca concentration of the children with different genotypes of VDR FokⅠwere 2.71 mmol/L for ff,2.39 mmol/L for Ff,and 2.48 mmol/L for FF.Serum Ca concentration in the children carrying ff genotype was significantly higher than that of the children carrying FF and Ff genotypes(P < 0.05).Conclusion This study provides the evidence of an association of ER PvuⅡ and VDR FokⅠpolymorphisms with osteocalcin and Ca in serum of children.
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2012, 28(8): 1104-1105. doi: 10.11847/zgggws2012-28-08-32
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2012, 28(8): 1128-1130. doi: 10.11847/zgggws2012-28-08-41
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2012, 28(8): 1134-1135. doi: 10.11847/zgggws2012-28-08-44
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2012, 28(8): 1135-1136. doi: 10.11847/zgggws2012-28-08-45
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