细胞色素P450基因1A1与肺癌类型病例对照研究

黄晓晖; 陈思东; 汪保国; 周卫平; 王德全

细胞色素P450基因1A1与肺癌类型病例对照研究

A case-control study of effect of CYP1A1 MspI polymorphisms on risk of histologic types of lung cancer

摘要

摘要:
目的研究肿瘤易感性标记物细胞色素P4501A1(CYP1A1)与肺癌类型的关系。
方法收集原发性肺癌91例和138例对照。所有研究对象均采血进行DNA提取, 采用多聚合酶链反应-限制性片段长度多态性(PCR-RELP)技术检测CYP1A1基因型。
结果鳞癌与CYP1A1突变型有关(OR=2.72, P=0.011)。吸烟与CYP1A1基因的联合作用未发现与不同类型肺癌有关系。对不吸烟者, CYP1A1杂合型可能是一个保护因素(OR=0.13, P=0.033), 降低其发生鳞癌的危险性。饮酒和CYP1A1突变型基因联合作用与鳞癌有关(OR=4.32, P=0.048), 和CYP1A1杂合型基因联合作用与腺癌有关(OR=22.00, P=0.009)。
结论 CYP1A1突变型基因型是肺癌的易感因素。

Abstract:
Objective To investigate the correlation of the genetic polymorphisms with CYP1A1 MspI with the risk of histologic types of lung cancer.
Methods Genotype frequencies of CYP1A1 MspI analyzed by PCR based RELP in 91 lungcancer and 138 controls.
Results The m₂m₂ gentype of CYP1A1 and the strong association for squamous cell carcinoma were observed(OR=2.72, P=0.011).There was no association observed between the other genotypes of CYP1A1 and squamous cell carcinoma and adenocarcinoma.Stratified analysis by smoking showed that there was no association observed between the genotypes of CYP1A1, and both squamous cell carcinoma and adenocarcinoma.But to the non-smoking, the m₁m₂ genotype of CYP1A1 maybe a protection factor(OR=0.13, P=0.033).However, stratified analysis by alcohol drinking suggested that m₂m₂ genotype of CYP1A1 was related to squamous cell carcinoma in the alcohol drinker(OR=4.32, P=0.048), and m₁, m₂ genotype of CYP1A1 was related to adenocarcinoma(OR=22.00, P=0.009).
Conclusion The m₂m₂ genotype of CYP1A1 is a susceptibility factor of lung cancer.

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