广东汉族人群谷胱甘肽硫转移酶A1基因多态性

Genetic polymorphism of glutathione S-transferas A1 in healthy Han population of Guangdong province

摘要:
目的探讨广东健康汉族人群谷胱甘肽硫转移酶A1(hGSTA1)基因多态性的分布。
方法采用聚合酶链反应-限制性片段长度多态性方法(PCR-RFLP)检测217名广东健康汉族人hGSTA1基因型。
结果 GSTA1基因野生型纯合子(GSTA1^*A/^*A)分布频率为76.0%(165/217), 突变型纯合子(GSTA1^*B/^*B)为2.8%(6/217), 突变型杂合子(GSTA1^*A/^*B)为21.2%(46/217);GSTA1基因多态性的性别分布差异无统计学意义(P > 0.05)。
结论广东健康汉族人群GSTA1基因多态性分布与日本人相似, 但与美国白人、美国黑人存在差异。

Abstract:
Objective To investigate the distribution of glutathione-S-transferase A1(GSTA1)gene polymorphism in Han population of Guangdong.
Methods The genotypes of GSTA1 in 217 Han people were detected by PCR-RFLP.
Results The GSTA1 genotype frequency for types of A^*/^*A, B^*/^*B and A^*/^*B were 76.0%(165/217), 2.8%(6/217)and 21.2%(46/217), respectively.There were no statistical differences between that of males and females(P > 0.05).
Conclusion The GSTA1 gene polymorphism in Guangdong Han population is similar to that in Japanese population, but significantly different form that in America white and black.