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冯福民, 刘茜, 郭梅, 王东, 高宝霞, 安雅臣, 纪春梅, 孙永红. 甘露糖结合蛋白基因突变与肺结核发病关系[J]. 中国公共卫生, 2006, 22(11): 1353-1355.
引用本文: 冯福民, 刘茜, 郭梅, 王东, 高宝霞, 安雅臣, 纪春梅, 孙永红. 甘露糖结合蛋白基因突变与肺结核发病关系[J]. 中国公共卫生, 2006, 22(11): 1353-1355.
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FENG Fumin, LIU Qian, GUO Mei, . Rlationship between mannose-binding protein P54 allele polymorphisms and susceptibility to pulmonary tuberculosis[J]. Chinese Journal of Public Health, 2006, 22(11): 1353-1355.
Citation: FENG Fumin, LIU Qian, GUO Mei, . Rlationship between mannose-binding protein P54 allele polymorphisms and susceptibility to pulmonary tuberculosis[J]. Chinese Journal of Public Health, 2006, 22(11): 1353-1355.
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甘露糖结合蛋白基因突变与肺结核发病关系

Rlationship between mannose-binding protein P54 allele polymorphisms and susceptibility to pulmonary tuberculosis

    摘要
  • 摘要:
      目的  探讨甘露糖结合蛋白(mannose-binding protein, MBP)基因多态性与中国人肺结核发病的关系。
      方法  采用病例对照研究方法, 收集126例肺结核病例和201名健康对照的环境因素暴露情况及静脉血, 采用特异引物PCR方法分析MBP基因多态性, 对各危险因素进行单因素分析和多因素非条件Logistic回归分析。
      结果  卡介苗接种史、卡痕、家族史与肺结核的发生有关。MBP-54位点野生型(G/G)、突变型杂合子(G/A)、突变型纯合子(A/A) 3种基因型在病例组和对照组中的分布频率不同。男性患者杂合子突变率高于对照组(OR =4.721, OR 95%CI = 1.463 ~ 15.236)。在多因素分析中调整卡介苗接种史、卡痕和家族史后, 男性MBP-54G/A基因型与肺结核发病差异仍有统计学意义(OR =7.304, 95 %CI为1.722 ~ 30.983)。
      结论  MBP -54位点G/A突变可能与肺结核发病相关。

     

    Abstract:
      Objective  To explore the association between the genetic polymorphisms of mannose-binding protein(MBP)P54 allele and susceptibility to pulmonary tuberculosis.
      Methods  126 cases and 201 controls were collected.Acase-control study was conducted.Polymerase chain reaction with sequence-specific primers(PCR-SSP)was carried out in the polymorphism in MBPgene.Information on related risk factors of tuberculosis was collected by using a pre-tested questionnaire.Univariate and multivariate logistic analyses were conducted with SPSS software package.
      Results  The vaccinal vestige, BCGimmunization and familial traits were the risk factors of tuberculosis.Frequency of wildness, mutantheterozygote and homozygote of MBP-54 was difference in cases and controls.The univariate analysis demonstrated that MBP-54 G/Ahomozygote genotypes occurred more frequently in the men cases than controls, with crude OR(95 %CI)being 4.721(1.463~15.236).After adjusting three related environmental factors(vaccinal vestige, BCGimmunization and familial traits)in the multivariate logistic analyses, the MBP-54 G/Ahomozygote genotypes were still significantly overrepresented in men cases, with adjusted OR(95 %CI)being 7.304(1.722~30.983).
      Conclusion  MBP-54 genotypes might be associated with the susceptibility to pulmonary tuberculosis.

     

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