Objective   To investigate the effect of the cytokine-vascular endothelial gro wth factor(VEGF), transform growth factor β₁(TGF-β₁), platelet-derived growth factor receptor-β(PDGFR-β)in the etiology of alcoholic fatty liver by setting up rat models of fatty liver, and also the changes of the cytokines in the progress of the treatment by simvastation and fenofibrate.

  Methods   Liver histological pathology was dyed by HE and analyzed under light microscope; liver immunohistochemical staining was performed by SABC technique to assess the cytokine-VEGF, TGF-β₁, PDGFR-β in hepatic tissue.

  Results   It was found post-treatment with drugs that there was significant improvement in pathology of alcoholic fatty liver model after treated with fenofibrate, but not with simavastatin.There was no significant differences after treated with finofibrate(P > 0.05), but an improved level post treated with simav astatin(P > 0.05); after treated with fenofibrate, there was decreased expression of TGF-β₁ and PDGFR-β, and a significant decrease of PDGFR-β after treated with simavastatin.

  Conclusion   Post-treated with alcohol, VEGF, TGF-β₁ and PDGFR-β were all possitive expressed in alcoholic fatty liver tissue, and a decreased expression post-treated with fenofibrate and simavastatin, which was parallel with the changes of pathology, and illustrated cytokines played roles in the etiology of alcoholic fatty liver.