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马燕花, 吴静, 严祥, 姬瑞. 食管癌中白细胞-DR抗原表达与幽门螺杆菌感染[J]. 中国公共卫生, 2005, 21(10): 1207-1208.
引用本文: 马燕花, 吴静, 严祥, 姬瑞. 食管癌中白细胞-DR抗原表达与幽门螺杆菌感染[J]. 中国公共卫生, 2005, 21(10): 1207-1208.
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MA Yanhua, WU Jing, YAN Xiang, . Study on association of HLA-DR antigen with esophageal carcinoma and Helicobacter pylori infection[J]. Chinese Journal of Public Health, 2005, 21(10): 1207-1208.
Citation: MA Yanhua, WU Jing, YAN Xiang, . Study on association of HLA-DR antigen with esophageal carcinoma and Helicobacter pylori infection[J]. Chinese Journal of Public Health, 2005, 21(10): 1207-1208.
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食管癌中白细胞-DR抗原表达与幽门螺杆菌感染

Study on association of HLA-DR antigen with esophageal carcinoma and Helicobacter pylori infection

    摘要
  • 摘要:
      目的   探讨人类白细胞抗原(HLA-DR)与食管癌及其临床特征和幽门螺杆菌(Hp)感染的相关性。
      方法   采用免疫组织化学技术卵白素-生物素-酶复合物(ABC)法和链霉素-过氧化物酶(S-P)法分别检测40例食管癌和30例正常食管粘膜(癌旁正常组织)中HLA-DR抗原的表达情况和幽门螺杆菌(Hp)的感染情况及其临床病理特征。所有标本常规HE染色进行病理诊断。应用SPSS 8.0统计软件进行统计学处理。
      结果   食管癌组织中HLA-DR抗原的阳性表达率为45.0%, 高于正常对照组的13.3%(χ2=7.977, P < 0.05), 且HLA-DR抗原在食管上皮内癌中的表达为71.4%, 高于浸润性食管癌中的表达30.7%(χ2=6.078, P < 0.05)。HLA-DR抗原在食管癌中的表达与患者的年龄、性别、肿瘤生长部位、淋巴转移、分化程度无相关性。食管癌组织中Hp的感染率为95.0%, 高于正常对照组的20%(χ2=41.302, P < 0.05)。Hp的表达与患者的临床病理特征即年龄、性别、生长部位、侵袭程度、淋巴转移、分化程度无相关性。
      结论   HLA-DR抗原表达和Hp感染与食管癌发生密切相关; HLA-DR抗原表达有益于防止肿瘤侵袭; HLA-DR抗原在食管癌中表达并不增加Hp感染的危险性。

     

    Abstract:
      Objective   To investigate the relation between the HLA-DR expression and Helicobacter pylori infection in esophageal carcinoma.
      Methods   HLA-DR was examined in 40 patients with esophageal carcinoma and 30 normal control subjects by immunohistochemistry technique(ABC)and relation between HLA-DR expression and clinicopathologic characteristics were analyzed. The status of H.pylori infection were determined by immunohistochemistry technique(S-P). All specimens were diagnosed through normal pathological process.
      Results   Positive rate of HLA-DR in esophageal carcinoma was 45.0%, which was significantly higher than 13.3% in normal controls(χ2=7.977, P < 0.05), the expression of HLA-DR in intraepithelial carcinoma was significantly higher than that in invasive carcinoma(χ2=6.078, P < 0.05). The infection rate of Hp in esophageal carcinoma was 95%, which was significantly higher than 20% in normal controls. No significant associations were found between patients with HLA-DR antigen and Hp infection with regard to patients' age at presentation, Sex, tumor site, lymph node metastases, histological grading of tumor.
      Conclusion   HLA-DR expression and Hp infection were associated with the incidence of esophageal carcinoma. The HLA-DR expression may prevent tumor invasion similarly to its role in intraepithelial carcinoma. The HLA-DR expression was not associated with the status of H.pylori infection.

     

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