Abstract:
Objective To study the toxicity mechanism of mice testicular cells by lead exposure.
Methods
Methods of SCGE (Single cell gel electrophoresis technique)and MTT were used.
Results There were different degree DNA damage of testicular cells by lead exposed to group(0.15%), group(0.3%), group(0.6%). The length of DNA migration were significant different to the control groups(P < 0.01). Lead restrained testicular cells proliferation. MDA level were increased and SOD and GSH activity were decreased.
Conclusion Lead caused oxidative damage and DNA break damage of mice testicular cells, and restrained testicular cells proliferation.