营养性肥胖大鼠血浆肾上腺髓质素水平变化

余上斌; 刘声远; 刘垒; 冯秀玲

营养性肥胖大鼠血浆肾上腺髓质素水平变化

Changes of adrenomedullin level in nutrient obesity rats

摘要

摘要:
目的观测营养性肥胖大鼠血浆肾上腺髓质素(ADM)水平变化以及心脏/体重、肝脏/体重比改变。
方法用特异性放免法测定血浆ADM含量; 称各组大鼠心脏、肝脏湿重, 并分别计算与体重之比。
结果肥胖大鼠血浆ADM水平(78.35±6.38)pg/ml明显低于正常体重大鼠(92.47±10.61)pg/ml(P < 0.05);心脏(g)/体重(g)、肝脏(g)/体重(g)比(0.319±0.019), (3.334±0.410)均明显高于普通饲料喂养组(0.225±0.020), (2.951±0.730)(P < 0.05)。
结论营养性肥胖大鼠血浆ADM水平降低, 在大鼠肥胖症的发生发展以及肥胖症大鼠心脏/体重、肝脏/体重比增大中可能起作用。

Abstract:
Objective To observe the changes of adrenomedullin(ADM)level in plasma and heart/weight, liver/weight rate in nutrient obesity rats.
Methods The concentration of ADM was determined by special radioimmunoassay, the weight of heart, liver and whole body were measured and the rate of heart/weight and liver/weight(g/g)were calculated respectively.
Results The plasma ADM level in obesity rats(78.35±6.38)pg/ml was lower than that in normal rats(92.47±10.61)pg/ml(P < 0.05);the rate of heart/weight(g/g)and liver/weight(g/g)of obesity rats(0.319±0.019), (3.334±0.410)were higher than those in normal groups (0.225±0.020), (2.951±0.730)(P < 0.05).
Conclusion Reduction of ADM level probably resulted in the occurrence and progression of nutrient obesity, and probably contributed to the increases of heart/weight and liver/weight.

HTML全文

参考文献(6)

施引文献

资源附件(0)