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胡大林, 刘移民, 唐冬生, 彭晓春, 荆春霞, 纪卫东, 胡恭华, 杨建平, 涂小志, 庄志雄. 游离SiO2环境污染与人红细胞膜脂质过氧化损伤[J]. 中国公共卫生, 2005, 21(10): 1273-1274.
引用本文: 胡大林, 刘移民, 唐冬生, 彭晓春, 荆春霞, 纪卫东, 胡恭华, 杨建平, 涂小志, 庄志雄. 游离SiO2环境污染与人红细胞膜脂质过氧化损伤[J]. 中国公共卫生, 2005, 21(10): 1273-1274.
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HU Dalin, LIU Yiming, TANG Dongsheng, . Relation between environmental pollution caused by free SiO2 dust and lipid peroxidation in erythrocyte membrane in human[J]. Chinese Journal of Public Health, 2005, 21(10): 1273-1274.
Citation: HU Dalin, LIU Yiming, TANG Dongsheng, . Relation between environmental pollution caused by free SiO2 dust and lipid peroxidation in erythrocyte membrane in human[J]. Chinese Journal of Public Health, 2005, 21(10): 1273-1274.
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游离SiO2环境污染与人红细胞膜脂质过氧化损伤

Relation between environmental pollution caused by free SiO2 dust and lipid peroxidation in erythrocyte membrane in human

    摘要
  • 摘要:
      目的   探索游离SiO2粉尘的环境污染与健康人外周血中红细胞膜的脂质过氧化损伤的关系为游离SiO2粉尘毒作用的预防和控制工作提供基础资料。
      方法   运用流行病学随机整群抽样研究方法, 抽取某市2家陶瓷企业进行横断面调查。对接触游离SiO2粉尘的人员179例及对照组57例进行检测, 并现场调查。均抽取外周静脉血样2 ml, 以肝素钠抗凝, 抽提红细胞膜, 以二硫代二硝基苯甲酸法测定谷胱甘肽过氧化物酶(GSH-px)活力, 以硫代巴比妥法(TBA)测定丙二醛(MDA)含量, 以黄嘌呤氧化酶法测定超氧化物歧化酶(T-SOD)活力, 以考马斯亮蓝法测定膜蛋白含量。
      结果   职业接尘人员红细胞膜GSH-px活力明显低于对照组(P < 0.05), MDA含量明显高于对照组(P < 0.05), SOD活力明显低于对照组(P < 0.05)。
      结论   游离SiO2粉尘的环境污染可造成职业接尘人员红细胞膜明显的脂质过氧化毒作用; 脂质过氧化损伤指标的变化可能为游离SiO2粉尘毒作用的某种临床前期危险信号; 维持机体抗氧化防御体系的动态平衡, 可能是实现游离SiO2粉尘毒作用二级预防的重要手段。

     

    Abstract:
      Objective   To explore the relation between air environmental pollution by free SiO2 dust and lipid peroxidation degree in erythrocyte embrane in human.
      Methods   179 healthy workers exposed to free SiO2 dust and 57 healthy members(control group)were sampled by cluster sampling method in two ceramics factories in Foshan city of Guangdong province, and a cross sectional investigation was carried out in up-related population and 2 ml blood in vein was draw from each one. Malondialdehyde(MDA), superoxide ismufase(SOD)and glutathion peroxidase(GSH-px)were tested by method introduced in reagent kits.
      Results   Activity of GSH-px in erythrocyte membrane in workers exposed to free SiO2 dust was significantly lower than that of control group(P < 0.05), the quantity of MDA in erythrocyte membrane in workers was significantly higher than that of control group(P < 0.05), and activity of SOD in workers was significantly lower than that of control group(P < 0105).
      Conclusion   Air environmental pollution by free SiO2 dust can cause significant toxicological reaction of lipid peroxidation in erythrocyte membrane in human, the change of degree of lipid perox idation maybe a certain kind of pre-clinical message, and sustain a stable balance state of anti-oxidation system maybe an important strategy for the secondary prevention of toxicological reaction caused by free SiO2 dust in human.

     

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