Abstract:
Objective To investigate the effect of purified water on hepatic expression of low density lipo profein receptor (LDLR)in rats.
Methods 60 male and female Wistar rats were equally randomized into 3 groups 〔tap water group(TW), pur ified water group(PW)and purified water+MgSO4 group(PW+Mg)〕, Levels of hepatic LDLR mRNA were examined by RTPCR after 6 months treatment.
Results Compared with the TW(control group), a decrease trend in LDLR of gene expression in PW and an increase trend in LDLR of gene expression in PW+Mg which compared with the PW were observed, but no differences were seen among all groups.
Conclusion Compared with the TW(control group), drinking PW group and PW+Mg group did not obviously affect the levels of hepat ic LDLR mRNA in rats.