广州市孕妇硒碘营养状况调查
Study on nutritional status of selenium and iodine of pregnant women in Guangzhou
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摘要:目的 了解广州市孕妇孕中、晚期硒碘营养状况。方法 用砷铈接触法测定尿碘, 用放射免疫分析法(RIA)测定血清甲状腺素(T4)、促甲状腺激素(TSH), 荧光光度法测定静脉全血硒。结果 孕中期血硒含量(0.1375±0.0969)μg/ml及孕晚期血硒含量(0.1528±0.0859)μg/ml, 远低于我国中硒区成人血硒值(0.35±0.02)μg/ml。孕中、晚期血硒含量无明显变化(P > 0.05)。孕中期尿碘中位数为249.3μg/L, < 100μg/L者占4.5%;孕晚期尿碘中位数为241.2μg/L, < 100μg/L者占12.5%, 两期尿碘值自身比较差异无统计学意义(P > 0.05)。孕中期血清T4(157.0±66.4)nmol/L, 在正常范围者占58.2%;孕晚期血清T4(124.4±59.4)nmol/L, 在正常范围者占78.3%。孕中期血清TSH(中位数3.9mU/L) > 5mU/L者占34.3%, 孕晚期血清TSH(中位数69mU/L) > 5mU/L者占81.8%。中晚期自身比较TSH > 5mU/L与 > 5mU/L的人数构成差异有统计学意义(P > 0.001)。结论 广州市孕妇硒碘营养状况良好, 孕晚期血清TSH > 5mU/L者(81.8%)较多, 与尿碘、T4水平不一致, 有待进一步研究。Abstract:Objective To investigate the nutritional status of selenium and iodine of pregnant women in Guangzhou.Methods The urinary iodine were measured by spectrophotometer.Content of tetraiodothyroxine(T4), thyroid stimulating hormone(TSH)in serum were deter mined by radioimmunoassay(RIA).The selenium in whole blood were determined by flu orometry.Results The selenium concentration in mid-pregnant blood and later-pregnant wo men blood was(0.137 5 0.096 9)μg/ml and(0.152 8±0.085 9)μg/ml, respectively.The median of urinary iodine in mid-and later-pregnant women was 249.3 and 241.2 μg/L, respectively.The proportions with ur inary iodine < 100μg/L in mid-and later-preg nant wo men was 4.5% and 12.5%, respectively.The aver age T4 level in mid-pregnant women was(157.0±66.4)nmol/L, 58.2% of whom were within 54-174 nmol/L(recommended rang).The average T4 level of later pregnant women was (124.4±59.4)nmol/L, 78.3% of whom were within 54-174 nmol/L.The proportion of TSH > 5 mU/L in mid-preg nant was 34.3% and was 81.8%(P < 0.01)in later pregnant.Conclusion The pregnant women in Guang zhou had good nutritional status of selenium and iodine.The propo rtion of TSH > 5 mU/L in later pregnant women was high(81.8%).
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