番茄红素对急性肝损伤大鼠抗氧化酶的影响

Effect of lycopene on antioxidative enzyme in acute liver damage rats

摘要:
目的观察四氯化碳急性中毒对大鼠机体抗氧化酶活力的影响及番茄红素(lycopene, LP)的保护作用。
方法大鼠灌胃番茄红素, 4周后以四氯化碳腹腔注射, 24h后处死, 测定血清和肝匀浆的超氧化物岐化酶(SOD)活性, 谷胱甘肽过氧化物酶(GSHPx)活力, 丙二醛(MDA)含量, 还原型谷胱肝肽(GSH)含量及总抗氧化能力(TAOC)。
结果与模型组相比, 各番茄红素组的大鼠血清和肝组织的SOD活性, GSHPx活力上升, MDA含量降低, GSH含量升高, TAOC升高, 差异有统计学意义(P < 0.05)。
结论番茄红素可以提高大鼠机体的抗氧化能力, 减轻四氯化碳对机体造成的肝损伤。

Abstract:
Objective To obser ve the protective effect of lycopene(LP)on acute injury induced by Carbon T etrachloride (CCl₄)in rats.
Methods Rats were given lycopene by oral.After 4 weeks the activ ity of super oxide disutase(SOD), malondi aldehyde(MDA)and glutathione peroxidase(GSH-Px), reduced glutathione(GSH), total-antioxidation capacity(T-AOC)in serum and liver were measured respectively.
Results The activities of antio xidative activity in model group were reducd.Compared with model group, the activities of SOD, GSH, TAOC and GSH-Px in LP group were increased and the concentrations of MDA were descreased significantly(P < 0.05).
Conclusion LP can incr ease antioxidative activity, and decrease the damage of liver in rats.