儿童1型糖尿病环境危险因素病例对照研究

任宏; 欧阳凤秀; 罗飞宏; 沈水仙; 姜庆五

儿童1型糖尿病环境危险因素病例对照研究

Case-control study on environmental risk factors of type 1 diabetes in Shanghai population

摘要

摘要:
目的探索1型糖尿病的环境危险因素。
方法采用1:4病例对照研究的方法。选择2003年5月~12月在复旦大学附属儿科医院内分泌病房住院或者门诊随访的上海地区1型糖尿病患儿40例, 配以160例从上海市社区人群中选取的未患1型糖尿病、身体健康的儿童为对照。使用单因素和多因素条件Logistic回归模型进行分析。
结果多因素条件Logistic回归分析结果显示, 儿童时期的感染、母亲孕期的被动吸烟史和孕期感染史与1型糖尿病的发生密切相关(P < 0.05), OR值分别为9.399, 22.361和12.833。
结论儿童时期的感染、母亲孕期的被动吸烟史和孕期感染史是儿童1型糖尿病的重要环境危险因素。

Abstract:
Objective To explore the environmental risk factors of type 1 diabetes in Shanghai.
Methods 1:4 matched case control study was used to carry out this investigation.Cases were forty children with type 1 diabetes who were in hospital or clinic follow-up in endocrine division in Children's Hospital Fudan Medical Unviersity from May to December, 2003.Controls were one hundred and sixty normal children selected from community in shanghai.Univariate and multivariate conditional Logisitic regression was used to analyze the database.
Results Results of the multiivar iate conditional Logisitic regressive analysis showed children's infection, passive smoking and infection in pregnancy had significant relationship with type 1 diabetes; the odds ratios were 9.399, 22.361 and 12.833 respectively.
Conclusion children's infection, passive smoking and infection in pregnancy were environmental risk factors of type 1 diabetes

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