2型糖尿病并发慢性病患者的生存分析

王翠玲; 刘美娜; 李永泉

2型糖尿病并发慢性病患者的生存分析

Survival study on type 2 diabetes mellitus with chronic complications

摘要

摘要:
目的用生存分析方法, 找出导致糖尿病慢性并发症的危险因素。
方法建立Cox回归模型, 计算个体预后指数(personal prognosis index, PI), 并比较PI值分组后的生存曲线。
结果微血管并发症的危险因素有年龄和家族遗传史; 大血管并发症的危险因素除上述两者外, 还有文化程度高、高血压和心脏病史及不良嗜好; 按PI值分组后, 高、中、低危组的大血管和微血管并发症发生率均有明显差异。
结论根据不同病人的预后指数PI, 临床医师可以有针对性的对糖尿病病人进行治疗, 以减少并发症的发生, 更好地提高糖尿病病人的生存质量。

Abstract:
Objective To find the risk factors of type 2 diabetes with chronic complications by means of the survival study.
Methods Aprognostic index (PI) based on the Cox's proportional hazards regression model was constructed.patients were classified to different hazard groups by PI and their kaplain-meir's survival curves were compared.
Results The risk factors of diabetic micro-angiopathy were age and inheritance; the risk factors of diabetic macro-angiopathy were age, inheritance, culture degree, bad habits and history of hypertension and cardiopathy.There were distinctly different among the 3 groups.
Conclusion PI may provide valuable information to physicians in the planning of treatment for individual duabetes patients in further clinical trials, so that it can help reduce the incidence of choronic complications and improve their quality of life at last.

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