宫内铅暴露对大鼠神经行为发育的影响

胡前胜; 任铁玲; 傅洪军; 董胜璋; 陈学敏

宫内铅暴露对大鼠神经行为发育的影响

Effect of low-level lead exposure in uterus on neurobehavioral development of rats

摘要

摘要:
目的研究低水平宫内铅暴露对Wistar大鼠早期行为及学习记忆等神经行为发育的影响。
方法雌性大鼠分别经0.5, 1.0和2.0mmol/LPbCl₂暴露后, 观察其F1代仔鼠断崖回避、平面翻正、前肢悬挂、空中翻正、听觉惊愕和视觉定位等早期行为发育以及应用水迷宫、Y迷宫检测仔鼠学习记忆能力。
结果孕鼠经2.0mmol/LPbCl₂染毒后, 其仔鼠听觉惊愕和视觉定位等行为指标的发育出现了延迟; 而1.0和2.0mmol/LPbCl₂染毒后的孕鼠, 导致其仔鼠的空中翻正发育延迟, 仔鼠的空间方位辨别学习能力和运动学习能力、短时记忆和长时记忆能力的损害。
结论宫内低水平铅暴露具有较强的行为发育毒性。

Abstract:
Objective To study the impact of low-level lead exposure in uterus on the neurobehavioral development of rats.
Methods Female Wistar rats were exposed to PbCl₂ at dosage of 0.5, 1.0 and 2.0mmol/L respectively, and their F1 pups were examined to observe the impact of lead on the early behavioral development such as cliff avoidance, surface righting, forelimb hanging, air righting, acoustic startle and visual placing.Water maze test and Y maze test were also done to detect the impact of lead on the development of learning and memory of rat pups.
Results 2.0mmol/L PbCl₂ exposed in uterus caused the F1 Wistar rat pup's.visual placing and acoustic startle development delaying; exposed to 1.0 and 2.0mmol/L PbCl₂ in uterus, the pup's air righting were delayed and their learning and memory abilities were impaired.
Conclusion Low-level lead exposure in uterus impaired the neurobehavioral development of rats significantly.

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