碘氟联用对大鼠红细胞膜磷脂和脂肪酸的影响

章子贵; 申秀英; 许晓路

碘氟联用对大鼠红细胞膜磷脂和脂肪酸的影响

Effect of combined iodine and fluoride on phospholipid and fatty acid composition of RBC in rat blood

摘要

摘要:
目的研究高氟及碘氟联用对大鼠红细胞膜磷脂和脂肪酸组成的影响。
方法选用SD大鼠, 饮用加氟(150mg/L)及同时分别加入不同浓度碘化钾(0.003, 0.03, 3mg/L)溶液共5个月, 用高效液相色谱法测定大鼠红细胞膜磷脂和肪肪酸含量。
结果高碘高氟组大鼠血液红细胞膜磷脂含量下降; 高氟组大鼠血液红细胞膜的不饱和脂肪酸下降, 饱和脂肪酸含量上升, 中等浓度的碘起到毒性协同作用。
结论长期摄入过量氟导致血液红细胞膜磷脂、脂肪酸组成改变, 不饱和脂肪酸减少, 这可能与自由基水平升高所造成的脂质过氧化增强有关; 一定浓度的碘可能对氟中毒大鼠血液中红细胞膜磷脂脂肪酸组成的影响有协同作用。

Abstract:
Objective To study the influence of high fluoride(F)and Indine(I)on phospholipid and its fatty acid composition of red blood cell(RBC)in rat blood.
Methods Five groups of rats were provided with deionized drinking water containing 0 and 150 mg/L NaF, and containing both 150 mg/L and 0.003, 03 or 3 mg/L KI respectively for 5 months.The plospholipid and its fatty acid composition were analysed using liquid chromatography.
Results Compared with control: the content of phospholipid decreased in the combinded of high I and high F group; the proportion of unsaturated fatty acids was decreased and the saturated fatty acids increased in the high F group; the middle conceneration I had cooperation effects on fluorosis.
Conclusion High amount of fluoride can induce modification of fatty acid compositions of phospholipid in blood, which might be the result from oxidative stress and the increased level of lipid peroxidation.

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