牛磺酸对染铅大鼠骨髓生化指标的影响

李秋莲; 高秋华; 薛承斌; 唐件荣; 林兴国

牛磺酸对染铅大鼠骨髓生化指标的影响

Effects of taurine on indexes of bone marrow in lead poisoned rats

摘要

摘要:
目的探讨牛磺酸(Tau)对染铅大鼠骨髓中一氧化氮(NO)、谷氨酸(Glu)信号分子等指标的影响。
方法将Wistar大鼠随机分为2组, 空白对照组和铅染毒组〔60mg/(kg·d)〕的醋酸铅灌胃, 然后将已染铅大鼠随机分为4组, 即铅对照组、3个牛磺酸治疗组〔200, 400, 800mg/(kg·d)〕。Tau治疗80d后处死动物, 测定血铅和骨髓中NO、一氧化氮合酶(NOS)、Glu、钙含量、巯基(SH)指标水平。
结果 (1) 各Tau治疗组大鼠血铅水平均低于铅对照组, 差异有统计学意义(P < 0.05或P < 0.01)。(2)Tau800mg组大鼠骨髓NO含量、总NOS活动、iNOS活力、巯基含量及Tau400mg组Glu含量与铅对照组比较, 差异有统计学意义(P < 0.05)。
结论 Tau能够调节铅暴露大鼠骨髓中信号分子NO、Glu的水平, 能够拮抗铅的骨髓毒性。

Abstract:
Objective To determine the effects of taurine on some signal transmitters and other indexes of bone marrow in lead poisoned rats.
Methods Wistar rats were divided into two groups: control group, lead group.1-30 day treated with lead acetate〔60 mg/(kg·d)〕.Then lead group were randomly divided into four groups: lead control group; group 1 lead+taurine, group 2 lead acetate〔60 mg/(kg·d)〕, group 3 different concentrations of taurine〔200, 400, 800 mg/(kg·d)〕.At the end of the experiment the rats were killed, the samples of blood and bone were taken for test.
Results (1) Blood lead contents in every lead-tau groups were all different from those in lead control group(P < 0.05 or P < 0.01).(2)After treating with taurine the content of nitric oxide(NO)and thiol, the activity of nitrite oxide synthase(NOS)and inducible NO synthase(iNOS)in bone marrow of 800 mg lead-Tau group were different from those in lead control group(P < 0.05).The content o glutamate of 400 mg lead-Tau group was different from those in lead control group(P < 0.05)as well.
Conclusion The taurine can modulate the disturbance of some signal transmitters in rats during lead poisoning to protect lead toxicity in bone marrow.

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