阴沟肠杆菌产诱导型β内酰胺酶及耐药性分析

李介华; 苏丹; 袁春雷

阴沟肠杆菌产诱导型β内酰胺酶及耐药性分析

Analysis on enterbacter cloacac inducible β-lactamase and drug resistance

摘要

摘要:
目的了解阴沟肠杆菌临床分离株产诱导型β内酰胺酶及其耐药性。
方法采用美国德灵DADE产Micro Scan Auto Scan-4型微生物分析仪及其NC21鉴定板和符合美国临床实验室标准化委员会(NCCLS)标准的VerSion22分析软件对103株阴沟肠杆菌检测产诱导型β内酰胺酶(IB)和对20种抗生素的敏感性。
结果以亚胺培南对阴沟肠杆菌的敏感性最高(89.3%)。其次为哌拉西林/三唑巴坦(63.1%), 其他18种抗生素的敏感性均 < 50%。103株阴沟肠杆菌中产IB者70株(68.0%)。阴沟肠杆菌产IB株对哌拉西林/三唑巴坦、阿米卡星、头孢他啶、头孢吡肟等抗生素的敏感性显著高于不产IB株(P < 0.005)。
结论抗生素诱导阴沟肠杆菌产IB率较高, 且耐药严重。

Abstract:
Objective To investgate the inducible B-lact amase producing(IB)isolated enter bacter cloacac and their bacterial resistance.
Methods 103 E.cloacac pro ducing IB and the susecptibility to 20 antibiotics were performed by Microscan Auto Scan-4 and plate NC21, version 22 analysis software according to the guidance of National Commitee for clinical Laboratory standards(NCCLS).
Results The sensitivity percentages to imipenem and piperacilin/tazobactam was 89.3% and 63.1% respectively; the other antibiotics were less than 50.0%.70 strains produced IB in 103 E.cloacac(68.0%), and their sensit ivities to iperacilin/tazobactam, amikacin, ceftazidime, cefepime et al were significantly higher than those of non-IB(P < 0.005).
Conclusion The rate of E.cloacac produce IB induced by antibiotics is high, and is severe resistance to antibiotics.

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