高级检索
孙珉丹, 林承赫, 邹洪斌, 迟宝荣. 未绝经汉族女性维生素D受体基因与骨钙素[J]. 中国公共卫生, 2004, 20(12): 1430-1431.
引用本文: 孙珉丹, 林承赫, 邹洪斌, 迟宝荣. 未绝经汉族女性维生素D受体基因与骨钙素[J]. 中国公共卫生, 2004, 20(12): 1430-1431.
shu
SUN Min-dan, LIN Cheng-he, ZOU Hong-bin, . Relationship between vitamin D receptor gene polymorphisms and osteocalcin[J]. Chinese Journal of Public Health, 2004, 20(12): 1430-1431.
Citation: SUN Min-dan, LIN Cheng-he, ZOU Hong-bin, . Relationship between vitamin D receptor gene polymorphisms and osteocalcin[J]. Chinese Journal of Public Health, 2004, 20(12): 1430-1431.
shu

未绝经汉族女性维生素D受体基因与骨钙素

Relationship between vitamin D receptor gene polymorphisms and osteocalcin

    摘要
  • 摘要:
      目的   了解维生素D受体(VDR)基因的限制性内切酶(BsmI)多态性在中国长春地区未绝经健康女性中的分布, 并进一步探讨其与骨钙素(BGP)的关系。
      方法   应用聚合酶链反应限制性片段长度多态性解析(PCRRFLPs)技术检测186例在长春地区生活10年以上无亲缘关系的未绝经健康汉族女性的VDR基因型, 用放免法测血清BGP, 同时考察它们之间的关系。
      结果   VDR基因型分布频率为Bb基因型23例(12.4%), bb基因型163例(87.6%), BB基因型缺如。b等位基因在本组人群中分布高达93.8%.各型的BGP分别为: Bb型(4.595±1.135)μg/L, bb型(4.534±1.267)μg/L.2组基因型的BGP比较, 无显著性差异(P>0.05)。
      结论   长春地区未绝经汉族女性的VDR基因型与BGP之间无相关关系。

     

    Abstract:
      Objective   To investigate the prevalence of polymorphism of the vitamin D receptor(VDR)gene in Chinese people, and to study the relationship between osteocalcin polymorphism of VDR gene.
      Methods   VDR (BsmI) gene polymorphisms of 186 healthy Pre-menopausal women was detected by using polymerase chain reation-restriction fragment length polymorphism(PCR-RELPs).The serum levels of osteocalcin were measured by radioim munoassay.
      Results   The frequency distribution of VDR gene type was BB 0%, Bb 12.4%, bb 87.6%, The b allelic frequencies reached as high as 93.8%.ANOVA Analysis indicated that there was no significant difference in BGP between the two groups of genotypes.
      Conclusion   There was no significant association of polymorphism in VDR gene with BGrP in Chinese pre-menopausal Han women in Changchun in this study.

     

    • HTML全文
    • 参考文献(9)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回