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姚平, 刘烈刚, 孙秀发, 宋方方, 周绍良, 章锡平, 祁振英, 于东. 银杏黄酮对雄性小鼠酒精性氧化损伤的保护[J]. 中国公共卫生, 2004, 20(12): 1432-1434.
引用本文: 姚平, 刘烈刚, 孙秀发, 宋方方, 周绍良, 章锡平, 祁振英, 于东. 银杏黄酮对雄性小鼠酒精性氧化损伤的保护[J]. 中国公共卫生, 2004, 20(12): 1432-1434.
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YAO Ping, LIU Lie-gang, SUN Xiu-fa, . Protective effects of flavonoids of Ginkgo Biloba on liver oxidative damage of male mice induced by chronic alcohol intakes[J]. Chinese Journal of Public Health, 2004, 20(12): 1432-1434.
Citation: YAO Ping, LIU Lie-gang, SUN Xiu-fa, . Protective effects of flavonoids of Ginkgo Biloba on liver oxidative damage of male mice induced by chronic alcohol intakes[J]. Chinese Journal of Public Health, 2004, 20(12): 1432-1434.
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银杏黄酮对雄性小鼠酒精性氧化损伤的保护

Protective effects of flavonoids of Ginkgo Biloba on liver oxidative damage of male mice induced by chronic alcohol intakes

    摘要
  • 摘要:
      目的   研究银杏黄酮对小鼠肝脏慢性酒精性氧化损伤的保护效应。
      方法   雄性小鼠给予银杏黄酮96mg/(kgºbw), 再给予乙醇3.2g/(kgºbw), 同时设正常对照组和酒精对照组〔乙醇3.2g/(kgºbw)〕, 连续灌胃75d后测定血清谷丙转氨酶(ALT)、谷草转氨酶(AST)活性及血清与肝脏谷胱甘肽(GSH)、谷胱甘肽过氧化物酶(GSH-Px)、超氧化物岐化酶(SOD)、过氧化氢酶(CAT)的活性及丙二醛(MDA)的含量。
      结果   小鼠摄入酒精75d后, 血清ALT、AST水平与正常对照组相比, 有显著性差异(P < 0.01), 肝脏及血清GSH-Px、SOD、CAT活性与GSH水平明显下降, MDA水平明显上升(P < 0.01);经银杏黄酮干预后, 与酒精对照组相比, 血清ALT、AST水平下降, 肝脏与血清GSH-Px、SOD、CAT活性与GSH水平升高, MDA水平下降。
      结论   银杏黄酮对小鼠肝脏慢性酒精性氧化损伤具有一定的保护作用。

     

    Abstract:
      Objective   To study the protective effects of flavo noids of ginkgo biloba on liver ox idative damage induced by chronic alcohol intakes in male mice.
      Methods   After pre-ingesting preventive reagent, flavonoids of ginkgo biloba〔96 mg/(kgºbw)〕, the male mice were treated by alcohol〔3.2 g ethanol/(kgºbw)〕via i.g, meanwhile, the normal control group and ethanol control group〔3.2 g ethanol/(kgºbw)〕were set up.The activity of glutamic-pyruvic transaminase(ALT)and glutamic oxaloacetic transminase(AST)in mice serum were measured, meanwhile, the concentration of glutathione(GSH), malondialdehyde(MDA)and the activity of glutathione per oxidase(GSH-Px), superoxide dismutase(SOD)and catalase(CAT) in the liver and serum were determined when the mice were continuously treated for 75 days.
      Results   The activity of AST and ALT in serum and MDA level in serum and liver increased significantly, and the activity of GSH-Px, SOD and CAT and GSH content decreased significantly(P < 0.01).The supplement of flavonoid of ginkgo biloba could significantly prohibit the rise of ALT, AST and MDA level and the decline of GSG-Px, SOD, CAT and GSH content which were induced by chronic alcohol intakes.
      Conclusion   Flavonoids of ginkgo biloba had some protective effects on oxidative damage of mice liver by chronic alcohol intakes.

     

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