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关英民, 李景舜, 赵淑华, 王春华. 四氯化碳对雄性小鼠肝损害及睾丸酶的影响[J]. 中国公共卫生, 2004, 20(12): 1464-1465.
引用本文: 关英民, 李景舜, 赵淑华, 王春华. 四氯化碳对雄性小鼠肝损害及睾丸酶的影响[J]. 中国公共卫生, 2004, 20(12): 1464-1465.
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GUAN Ying-min, LI Jing-shun, ZHAO Shu-hua, . Effect of carbon tetracholoride on male mice liver and testes enzyme[J]. Chinese Journal of Public Health, 2004, 20(12): 1464-1465.
Citation: GUAN Ying-min, LI Jing-shun, ZHAO Shu-hua, . Effect of carbon tetracholoride on male mice liver and testes enzyme[J]. Chinese Journal of Public Health, 2004, 20(12): 1464-1465.
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四氯化碳对雄性小鼠肝损害及睾丸酶的影响

Effect of carbon tetracholoride on male mice liver and testes enzyme

    摘要
  • 摘要:
      目的   观察四氯化碳大剂量染毒后对雄性小鼠肝和睾丸的损伤作用。
      方法   实验组动物给予10%CCl4灌胃, 剂量为0.2ml/10(g°bw)。对照组给予植物油。在染毒24h后处死动物, 测定肝脏的谷氨酸丙酮酸转移酶(ALT)、丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱苷肽过氧化物酶(GSH-Px)和山梨醇脱氢酶(SDH)、乳酸脱氢酶(LDH)、葡萄糖-6-磷酸脱氢酶(G-6-PD)的活性。
      结果   肝脏的MDA含量和SOD、GSHPx活性均明显高于对照组, 谷丙转氨酶(GPT)含量明显低于对照组, 睾丸中的LDH活性明显下降, 而SDH和G-6-PD活性未见明显变化。
      结论   四氯化碳可致肝脏的脂质过氧化损伤, 并对睾丸组织中的酶活性有损伤作用。

     

    Abstract:
      Objective   To observe the injury effect on the testes and liver in mice caused by carbon tetracholoride.
      Methods   The treat group mice were given0.2 ml/10(g°bw)of 10% carbon tetracholoride through i.g.The control group mice were given cigetable oil.After 24h injection, the mice were killed and the activity of GPT, SOD and GSH-Px and the content of MDA, in the liver and SDH, LDH, G-6-PD in the testes were determined.
      Results   The content of MDA、the activity of SOD and GSH-Px in the liver in the treat group were higher than those of the control group(P < 0.05).The content of ALT in the treat group was lower than that of the control group(P < 0.05).The activity of LDH in the tests in the treat group was higher than that of the control group(P < 0.05).There was no obvious difference in the activity of SDH and GSH-Px in the tests between the treat group and the conrol group.
      Conclusion   The carbon tetracholoride can cause the lipid peroxidation injury of the liver and damage the activity of the enzyme in the testes.

     

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