广东省不同人群SARS病毒抗体水平调查
Study on population immunity to SARS in Guangdong province
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摘要:目的 对不同人群进行SARSIgG抗体水平检测, 分析SARS流行规模和特征, 评价暴露的危险性, 了解人数中是否存在SARS病毒隐性感染, 为寻找SARS病毒传染源提供线索。方法 抽取7708份不同人群标本, 按临床症状和暴露因素分为临床确诊SARS病人、病人或污染物的接触者、普通健康人群和动物销售人员4类, 采用酶联免疫方法(ELISA)进行SARSIgG抗体检测, 用免疫荧光法(IFA)复核, 并结合流行病学资料进行分析。结果 127例临床确诊SARS病人抗体阳性率为66.9%;密切接触者中女性发病率高于男性; SARS病人或其污染物的密切接触者抗体阳性率为0.88%;动物销售人员为13.4%;野生哺乳动物销售者的抗体阳性率显著高于其他动物销售者, 普通健康人群未检出抗体阳性。低年龄健康人群ELISA检测阳性率为2.06%, 高于总体水平。结论 人群总体抗体水平很低, 普通健康人群无SARS冠状病毒抗体, 但可能存在某种可与SARS冠状病毒起交叉反应的抗体; 有无接触史是影响抗体阳性率的重要因素; 密切接触者可能存在隐性感染; 野生动物可能是本次SARS的传染源。Abstract:Objective To analyze epidemic scale and characteristic of the outbreak of SARS, evaluate the risk of exposure to SARS CoV.Methods A total of 7708 cases were divided into 4 groups including clinically confirmed patients, close contacts, animal traders and general people. SARS CoV-IgG was detected by ELISA and IFA. The epidemiological data was analyzed by SPSS.Results Positive rate in 127 clinically confirmed patients group was 66.9%, while 0.88% in close contacts group, 13.4% in animal traders group and 0 in general people. There was higher positive rate of wild animal salesman with 58.9%.The incidence of female close contacts was higher than that of male.Conclusion The positive rate of antibody in whole people was still very low and there were no antibody to SARS CoV in general healthy people. But there exited some cross-reaction antibody to SARS CoV in some people. Contact history was an important factor to the existence of SARS-CoV antibody. There existed recessive infection in close contacts, wild animals maybe the source of SARS.
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