eNOS基因变异与超重对早发冠心病的影响

贾崇奇; 宁艳; 刘同涛; 刘兆兰

eNOS基因变异与超重对早发冠心病的影响

Interaction between G894T mutation of endothelial nitric oxide synthase gene and overwieight in premature coronary heart disease

摘要

摘要:
目的探讨内皮型一氧化氮合成酶(eNOS)基因第7外显子G894T(Glu298Asp)变异与超重交互作用对早发冠心病的影响。
方法采用以医院为基础的病例对照研究方法, 选择新诊断的冠心病患者为研究对象; 男性55岁以前及女性65岁以前患冠心病为早发冠心病; 以132例早发冠心病患者为病例, 172例迟发冠心病患者为对照组。运用PCR-限制性片段长度多态性检测G894T变异; 用相加模型分析G894T变异与超重的交互作用。
结果 G894T变异与超重之间对早发冠心病具有正交互作用, 协同效应指数(S)为1.45;交互效应超额相对危险度(RERI)为1.32;归因交互效应百分比(AP)为25.06%。用多元Logistic回归调整性别、吸烟、饮酒、腰臀比、甘油三酯、总胆固醇后, G894T变异与超重之间对早发冠心病仍具有正交互作用。调整上述混杂因素后, S为1.43;RERI为2.76;AP为27.21。
结论 eNOS基因G894T变异与超重在早发冠心病的患病中存在明显的正相加模型交互作用, 使早发冠心病患病危险性增加近3倍; G894T变异与超重同时存在时, 早发冠心病患病危险性中约27%是由于两者交互作用所导致。

Abstract:
Objective To assess the interaction between G894T (Glu298Asp)mutation of endothelial nitric oxide synthase (eNOS) gene and overweight in premature coronary heart disease(P-CHD).
Methods Hospital-based case-control study was used. The newly-diagnosed CHD patients were recruited as the subjects. The 132 CHD patients diagnosed before ageless than or equal to 55 years old for male and 65 years old for female were appointed as the P-CHD and the case group, other 172 CHD patients as the control group. Polymerase chain reaction with Ban Ⅱ restriction enzyme digestion was performed to detect the G894T mutation.
Results There was a positive interaction between G894T mutation and overweight in P-CHD. The synergy index (S)was 1.45, the relative excess risk due to interaction(RERI)was 1.32, and the attributable proportion due to interaction(AP)was 25.06%.After adjusting sex, smoking, alcohol drinking, waist-hipratio, serum triglyceride, serum total cholesterol by logistic regression, there was also positive interaction between G894T mutation and overweight in P-CHD. The S was 1.43, RERI was 2.76, AP was 27.21%.
Conclusion The interaction between G894T mutation of eNOS gene and overweight had a positive effect on the P-CHD in this studied population.

HTML全文

参考文献(10)

施引文献

资源附件(0)