洪涝灾区健康人群免疫水平及控制钩体病对策
Countermeasures for preventing and controlling leptospirosis and the immune level of health population in flooding areas
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摘要:目的 调查洪涝灾区健康人群免疫水平, 探讨洪涝灾区控制钩体病流行对策。方法 选择湖北省仙桃、宜都市, 公安县等钩体病流行较为严重的地区作为调查点, 进行血清学等调查。结果 近年洪灾频繁发生, 钩体病传染源扩散较快, 健康人血清隐性感染率较高, 公安县以黄疸出血群和流感伤寒群免疫水平较高, 仙桃和宜都市以黄疸出血群和波摩那群免疫水平较高, 健康人血清钩体IgG显著高于IgG抗体。健康人血清黄胆出血群、波摩那群、流感伤寒群抗体阳性率分别为27.61%, 13.73%, 11.68%, 分别低于10年前平均水平20%~54%。结论 首次定量调查健康人血清钩端螺旋体IgG和IgM抗体水平, 奠定了我省健康人钩端螺旋体免疫水平测定、钩端螺旋体疫苗效果测定和钩端螺旋体病人诊断基础。控制钩体病的流行应采取接种钩体菌苗等综合性防治措施。Abstract:Objective Discussing the countermeasures for controlling prevalence of leptospirosis by investigating the influence of flooding toward prevalence factors of leptospirosis.Methods The serology investigation was carried out in Xiantao、Yidu、Gongan, where the epidemic situation were more serious.Results The infectious sources scattered quickly and the rate of recessive infection was high in the health population because of recent years flood. The antibody titer of Icterohaemorrhagiae、Grippotyphosa was higher in Gongan and Icterohaemorrhagiae、Pomona in Xiantao、Yidu; the rate of positive antibody of Ieterohaemorrhagiae、Pomoma、Grippotyphosa was 27.61%、13.73%、11.68%, lower 20%-54% than 10 years ago respectively in the health population.Conclusion The quantified serum antibody titer of IgG、IgM of leptosprisis was tested first among health population, establishing the foundation for determining the immune lever and the efficiency of vaccination and the diagnosing for leptospirosis. To prevent and control epidemic, the integrating measures must be taken.
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