急性白血病危险因素的多元Logistic回归分析

Logistic regression analysis on risk factors of acute leukemia

摘要:
目的探讨急性白血病的可疑危险因素。
方法对122例15岁以上的急性白血病患者进行1:1配对的病例-对照研究, 调查患者的既往病史、用药史、居住环境、职业暴露史、家居装潢史、吸烟史、染发史、家族肿瘤史等, 并应用条件Logistic回归模型进行分析。
结果 47项指标中有10项在单因素分析中有统计学意义, 6项在多因素分析中有统计学意义, 分别是解热镇痛类药物服用史、氯霉素服用史、X线接触史、化学有机溶剂接触史、家居装潢至搬入间隔和染发频率。
结论上述危险因素的存在增加了罹患急性白血病的风险。

Abstract:
Objective To explore suspicious risk factors of acute leukemia.
Methods 1:1 case control study was applied to investigate acute leukemia patients aged 15 and elder with conditional Logistic model.
Results In the single factor analysis, 10 of 47 indexes were obviously significant. While 6 of 47 indexes were obviously significant in the multi-factor stepwise analysis, which including febrifuge and anodyne administration, chloromycetin administration, exposure to X-ray, chemical organic solvents, interval of moving in aafter house decoration, frequency of hair dye use.
Conclusion The existence of these factors might increase the risk of acute leukemia.