高级检索
朱燕萍, 金念祖, 周建伟, 茅力, 赵人琤, 童建. 槲皮素在苯并芘致小鼠DNA损伤中的作用[J]. 中国公共卫生, 2004, 20(11): 1333-1335.
引用本文: 朱燕萍, 金念祖, 周建伟, 茅力, 赵人琤, 童建. 槲皮素在苯并芘致小鼠DNA损伤中的作用[J]. 中国公共卫生, 2004, 20(11): 1333-1335.
shu
ZHU Yan-ping, JIN Nian-zu, ZHOU Jian-wei, . Effect of quercetin on benzo[a]pyrene-induced DNA damage in mice[J]. Chinese Journal of Public Health, 2004, 20(11): 1333-1335.
Citation: ZHU Yan-ping, JIN Nian-zu, ZHOU Jian-wei, . Effect of quercetin on benzo[a]pyrene-induced DNA damage in mice[J]. Chinese Journal of Public Health, 2004, 20(11): 1333-1335.
shu

槲皮素在苯并芘致小鼠DNA损伤中的作用

Effect of quercetin on benzoapyrene-induced DNA damage in mice

    摘要
  • 摘要:
      目的   研究槲皮素在苯并芘致小鼠DNA损伤中的作用。
      方法   小鼠一次性腹腔注射苯并芘(BaP)100mg/kg后, 分别以0.5, 10, 2.0g/(kg·d)剂量的槲皮素连续灌胃90d。取小鼠尾部静脉血进行单细胞凝胶电泳实验, 通过荧光显像的方法观察并测量血细胞的拖尾长度。
      结果   阴性对照组小鼠的细胞无拖尾现象, 高、中、低剂量槲皮素组和苯并芘阳性对照组的细胞均有拖尾现象。对彗尾进行统计学分析, 与对照组相比, 各剂量组均有显著性差异(P < 0.05)。染毒组用不同剂量的槲皮素处理后, DNA的损伤程度显著减少。
      结论   槲皮素对苯并芘引起的小鼠DNA损伤有显著的保护作用。

     

    Abstract:
      Objective   To study the effect of quercetin on DNA damage induced to benzoapyrene in mice.
      Methods   Male and female ICR mice received one ip injection of benzoapyrene(100 mg/kg), then were fed with quercetin at the doses of 0.5, 1.0, 2.0 g/(kg·d)for three months. The single cell gel electrophoresis(SCGE)was used to study the DNA damage of mouse blood cell.
      Results   Mice treated with benzoapyrene had cometlength, whereas normal mice had no cometlength. After being treated with high, middle and low doses of quercetin for 3 months, the ratio of DNA damage and tail movement showed significant difference compared with the control (P < 0.05), which showed significant dose-effect relationships.
      Conclusion   Quercetin can prevent DNA damage from benzoapyrene.

     

    • HTML全文
    • 参考文献(5)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回