阿司匹林对鼠肝癌前结节的抑制作用

Inhibitory effects of ASA on evolution of preneoplastic lesion into nodules in rat hepatocarcinogenesis

摘要:
目的观察阿司匹林(ASA)对鼠肝癌前病灶(Foci)转化为增生结节(nodule)过程的抑制作用。
方法复制大白鼠肝癌前病灶发生的动物模型。然后将带有癌灶的大鼠分组。实验组分别给1%, 0.75%ASA, 加或不加0.05%苯巴比妥(PB)的饲料, 对照组只给单纯0.05%PB饲料或基础饲料喂养9周。处死取肝后, 进行r谷胺酰转换酶(GGT)组化染色和HE染色。
结果 1%, 0.75%ASA、分别加有或不加PB实验组中, 单位面积GGT染色阳性的持续性结节数及HE染色单位面积肝细胞增生性结节数显著减少(P < 0.05)。
结论两种浓度的ASA在有或没有PB的作用下, 都对肝癌前病灶转化为增生性结节的过程有抑制作用.

Abstract:
Objective To investigate inhibitory effects of aspirin(ASA)on the evolution of preneoplastic foci into nodules in rat liver.
Methods To make of producing preneoplastic foci, then rats bearing foci were given diets containing 1%、0.75% ASA with or without 0.05% phenobarbital(PB), 0.05% PB alone and basal diet for 9 weeks. Liver slices made GGT staining and HE staining.
Results Both doses ASA either with or without PB accelerated the remodeling of preneoplastic foci, significantly decreased the numbers of persistent nodules and hyperplasticc nodules.
Conclusion Both doses ASA inhibited the evolution of preneoplastic foci into nodules in rat liver with or without PB exposure.