Abstract:
Objective To explore the dynamic effect of aluminium on the concentration of extracellular Ca2+ in the cerebral cortex and hippocamp neurons.
Methods Wistar rats were randomly divided into four groups based on their body weight. Aluminium chloride was administrered by oral at doses of 248.7, 74.7, 37.3 and 0 mg/kg for 120 days successively.Fura-2/AM calcium ions fluorescence indicator was used to measure concentration on Day 45, 75, 120 and 30 after stopping Al3+ exposure.
Results 248.7 and 74.7 mg/kg groups had higher concentration of extracellular Ca2+ than the control group and the 37.3 mg/kg group had no significant difference between the control group. And if stopping Al3+ exposure, the concentration would recover.
Conclusion Al3+ can show the neurotoxic effect by raising the concentration of extracellular Ca2+ in the cerebral cortex and hippocamp neurons.