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岳伟, 金晓滨, 潘小川, 丁剑. 室内甲醛与成人过敏性哮喘关系的研究[J]. 中国公共卫生, 2004, 20(8): 904-906.
引用本文: 岳伟, 金晓滨, 潘小川, 丁剑. 室内甲醛与成人过敏性哮喘关系的研究[J]. 中国公共卫生, 2004, 20(8): 904-906.
YUE Wei, JIN Xiao-bin, PAN Xiao-chuan, . Relationship between indoor air formaldehyde exposure and allergic asthma in adults[J]. Chinese Journal of Public Health, 2004, 20(8): 904-906.
Citation: YUE Wei, JIN Xiao-bin, PAN Xiao-chuan, . Relationship between indoor air formaldehyde exposure and allergic asthma in adults[J]. Chinese Journal of Public Health, 2004, 20(8): 904-906.

室内甲醛与成人过敏性哮喘关系的研究

Relationship between indoor air formaldehyde exposure and allergic asthma in adults

  • 摘要:
      目的   探讨室内甲醛暴露与成人过敏性哮喘之间的关系。
      方法   采用病例-对照流行病学研究设计, 通过问卷收集30例成人过敏性哮喘患者及81例健康对照相关信息并测定111户研究对象室内空气中甲醛浓度。
      结果   病例组室内甲醛浓度总体分布高于对照组, 且具有显著性差异(P < 0.0001)。将甲醛浓度从低到高分为4个等级, 以等级1作为参考组, 可见其余各等级在病例组和对照组中的OR值不断增大; 调整了年龄、性别、目前吸烟及慢支/哮喘家族史后其相应的OR值也不断增大; 同时总趋势OR值表明在调整混杂因素前后, 甲醛浓度平均升高一个等级可以使哮喘的危险性分别增加2.51倍和2.36倍。结果表明, 室内甲醛每升高1个单位(μg/m3), 可以使成人过敏性哮喘的危险性提高0.02倍。同时本研究也表明, 装修可以使家庭室内甲醛浓度平均升高30.65μg/m3
      结论   随着室内甲醛浓度的升高, 哮喘及其发作的危险性逐渐增加, 两者之间具有一定的剂量-反应关系, 但只有当室内甲醛达到一定的高浓度水平时, 其对哮喘的危险性才会显现出来。

     

    Abstract:
      Objective   To investigate whether there was a relationship between the indoor air formaldehyde exposure and allergic asthma in adults.
      Methods   The case-control study method was used to collect the information of the 30 cases and 81 controls.All 111 subjects' indoor air samples were collected and assayed for the concentrations of formaldehyde by standard methods.
      Results   The concentration of the indoor air formaldehyde was higher in cases than that in controls and the difference had statistical significance(P < 0.000 1).After ranking the concentration of formaldehyde into 4 quarters, comparing with the first quarter, the other 3 quarters' unadjustedOR values were increasing respectively and after adjusting for age, gender, present smoking and family chronic bronchitis or asthma history, the OR values were increasing also.Meanwhile, the total trend OR value showed that the risk of the adults' allergic asthma would be increased 2.51 times(unadjusted)and 2.36 times(adjusted)with each quarter increasing of the indoor air formaldehyde concentration.Furthermore, the risk of the adults' allergic asthma would be increased 0.02 times than before when the indoor air formaldehyde concentration increasing each 1μg/m3.Simultaneously, the study also indicated that decoration could increase the indoor air formaldehyde concentration 30.65μg/m3 averagely.
      Conclusion   There was a definite dose-response relationshtp between the adults' allergic asthma and indoor air formaldehyde exposure.But the obvious risk would be showed up only when the concentration of the indoor air formaldehyde reached to a certain high level.

     

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