Abstract:
Objective To evaluate the effects of sulfur mustard(SM)on reproduction organs in medium and long term.
Methods Ten dogs were used as the animal model, four in control group while six in treatment group.Halfan hour after subcutaneously injected with 12 mg/(kg·body weig ht)of SM, the dogs of the treatment group were treated by medication.The dogs died of poisoning in control group and living dogs were anatomized.Microscope was used to observe pathological changesingerm cells.
Results Three dogs in control group died in three days after poisoning, dogs in treatment group all survived.The damnification of ovary cells can berecovered in about a month, while the damnification of spermary cells became more severe after a month.
Conclusion SM had obvious long-termtoxic effect on male germ cells, and generic therapeutic measures could not accelerate the recovery of germ cells in short time.
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