家族性2型糖尿病与心血管病危险因素研究

周金意; 周玲; 成金罗; 沈默宇; 王劲松

家族性2型糖尿病与心血管病危险因素研究

Study on relation between multiple familial type 2 diabetes mellitus and cardiovascular risk factors clustering

摘要

摘要:
目的研究2型糖尿病家系人群的心血管疾病危险因素聚集情况。
方法选择有2个或2个以上2型糖尿病患者的家系115个, 共有287例患者为病例组, 非糖尿病亲属168人为对照组, 进行病例-对照研究。应用χ ²检验、二项分类Logistic回归方法分析病例组和对照组的心血管疾病危险因素检出率及聚集性。
结果病例组、对照组心血管疾病危险因素聚集检出率分别为82.2%和53.0%; 二项分类Logistic回归分析显示心血管疾病危险因素聚集是2型糖尿病的独立危险因素, 其OR值为2.201。
结论心血管疾病危险因素聚集是家族高发性2型糖尿病的主要危险因素。

Abstract:
Objective To study the relation between multiple familial type 2 diabetes mellitus and cardiovascular risk factors clustering.
Methods 115 pedig rees with two orover two T2DM patients were chosen.The case-control study was carried out, which included 287 type 2 diabetes and 168 relatives with normal glucose tolerance.The statistic methods, such as Chi-square test and Binary Logistic Regression were used to study the relationship between type 2 diabetes mellitus and cardiovascular risk factors clustering.
Results The rates of risk factors clustering among case group and control group were 82.2% and 53.0% respectively.The results of Binary Logistic Regression indicated that cardiovascular risk factors clustering was a independent risk factor of T2DM, and the odds ratio was 2.201.
Conclusion Car diovascular risk factors clustering may be a main risk factors of multiple familial type 2 diabetes mellitus.

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