骨质疏松症危险因素的Meta分析<sup>*</sup>

骨质疏松症危险因素的Meta分析^*

摘要:
目的综合评价骨质疏松症发生的主要危险因素。
方法利用Meta分析对1993~2003年发表的骨质疏松发病危险因素研究文献进行综合分析, 通过计算合并似然比(OR)进行评价。
结果统计分析文献12篇, 合计样本量2756例, 其中病例数1228例, 对照数1528例。各因素合并后的OR值分别为: 年龄≥60为3.56, 体育锻炼不足为2.83, 钙摄入不足为2.33, BMI < 20为2.06, 吸烟为1.98, 饮酒为1.70。
结论改变不良生活习惯, 加强体育锻炼, 增加钙等营养摄入可减缓骨质疏松发生和发展。

Abstract:
Objective To provide evidence for osteoporosis(OP)prevention and control though probing the main risk factors related to the incidence of OP.
Methods The result of 12 epidemiological studies on risk factors of OP from 1993 to 2003 were analyzed by Meta analysis, and odds ratio(OR)was the effect index.The number of case and control were 1 228 and 1 528, respectively.
Results The pooled OR value are agedness(3.56), insufficient physical activity(2.83), low level dietary calcium(2.33), BMI under 20(2.06), smoking(1.98)and alcohol consumption(1.70).
Conclusion Changing the bad living habit and increasing dietary nutrient can make for prevention of OP incidence.