口服胰岛素对1型糖尿病小鼠预防与治疗作用

Effects of oral administration of porcine insulin on type 1 diabetes prevention and treatment in rat

摘要:
目的探索口服胰岛素引起的免疫耐受对1型糖尿病的预防与治疗作用。
方法将4周龄雌性非肥胖型糖尿病(NOD)小鼠随机分成4组, 任选3组从鼠龄4周、8周和12周起开始灌胃给予1mg胰岛素, 对照组从鼠龄4周起灌胃给予PBS。4组均持续灌胃到鼠龄35周。
结果各胰岛素给药组小鼠的1型糖尿病累计发病率均显著低于对照组(P < 0.01), 生存率显著高于对照组(P=0.009)。
结论口服胰岛素对1型糖尿病具有预防与治疗作用。

Abstract:
Objective To validate the preventive and therapy effects for type 1 diabetes with oral administration of porcine insulin.
Methods Forty female NOD mice were divided randomizedly into four groups.Begining from four, eight and twelve-week age, tree groups were orally administered porcine insulin 700 l(1 mg)and other 500 l PBS only.Twice before the twelfth week and then once weekly until 35-week age.
Results When the mice were thirty-five-week age, the cummulative incidences of all insulin groups were significantly lower than the control group(P < 0.01), but the survival rates were significantly higher than the control one(P=0.009).
Conclusion Oral administration of porcine insulin can not only prevent but also cure the type 1 diabetes.