广州市交警谷胱苷肽转硫酶基因多态性研究

楚心唯; 朱文昌; 陈清; 吴敏; 张维森; 江朝强; 陈思东

广州市交警谷胱苷肽转硫酶基因多态性研究

Study on GSTM1 genetic polymorphism in traffic police population in Guangzhou

摘要

摘要:
目的调查广州市交通警察人群谷胱苷肽硫酶GSTM1(Glutathione S-transferases M1)基因多态性分布。
方法采用人群普查和多重差异PCR(multi-differential Polymerase chain reaction, MD-PCR)方法对广州市交通警察外周血白细胞DNA的GSTM1基因缺失型进行检测, 比较GSTM1基因在性别、籍贯、民族、家族肿瘤史、工作性质、工龄及每周接触汽车废气时间等方面的分布, 并与其它地区人群进行比较。
结果广州市2093名在岗交通警察GSTM1基因缺失率为59.58%, 高于上海市区人群48.86%(P < 0.05), 低于云南籍肺癌人群76.79%(P < 0.05)。性别、籍贯、民族、肿瘤家族史、工作性质、工龄每周接触汽车废气时间等方面没有显著性差异(P > 0.05)。
结论研究人群GSTM1基因呈多态性分布, 其等位基因和基因型率在研究人群内部分布无显著性差异。

Abstract:
Objective To investigate the polymorphism distribution of the GSTM 1 genotypes in traffic police population in Guangzhou.
Methods The epidemiological data were collected by a cross-sectional study and GSTM 1 polymorhisms were determined by the multi-differential polymerase chiain reaction(MD-PCR)method using the samples of peripheral blood leukocyte DNA.Individuals were stratified according to their sex, native place, race, cancer family history, job and duration of exposure.The frequency of GSTM 1-null genotype in traffic police population in Guangzhou was compared with that of other population in China.
Results The frequency of GSTM 1-null genotype came to 59.58% in the study population, which was higher than that of urban population in Shanghai normal population and lower than that of lung cancer population in Yunnan (P < 0.05).However, no significant differences were found between GSTM 1-mull genotype and sex, nationality, work group, family cancer history, length of service and work environment, exposed automobile more than 10 hours per week(P > 0.05).
Conclusion Distribution of the GSTM 1 genes was polymorphic and GSTM-null genotype was similar in the characteristics of the study population.

HTML全文

参考文献(8)

施引文献

资源附件(0)