营养素对酒精性脂肪肝大鼠的干预作用

Effects of nutrients on alcoholic fatty liver in rats

摘要:
目的研究复合营养素对酒精性脂肪肝大鼠的干预作用及其机制。
方法用高脂饲料+乙醇灌胃建立酒精性脂肪肝大鼠模型, 干预组在造模同时给予营养素, 实验4周后处死, 做病理切片, 测定转氨酶、脂类和脂质过氧化。
结果营养素干预可明显降低血清谷草转氨酶(AST)、谷丙转氨酶(ALT)和γ-谷氨酰转肽酶(γ-GT)水平; 对血清和肝脏的甘油三酯(TG)、总胆固醇(TC)和游离脂肪酸(FFA)也有明显的降低作用; 同时肝脏氧化型谷胱甘肽(GSSG)和脂质过氧化物(LPO)明显降低。
结论营养素干预对酒精性脂肪肝大鼠有明显的改善作用。

Abstract:
Objective To examine the effects of complex nutrients on alcoholic fatty liver in rats.
Methods High fat and ethanol induced alcoholic fatty liver models, and the intervention groups received nutrients before gavaging ethanol.After 4 weeks, all the rats were killed.The hepatic samples were taken for pathological section, and transaminases, lipids and lipid peroxidation were also estimated.
Results The concentrations of serum AST、ALT and γ-GT, as well as TG, TC and FFA levels in intervention groups decreased significantly.Hepatic GSSG and LPO concentrations decreased severely in intervention groups also.
Conclusion The intervention nutrients played an important role in preventing alcoholic fatty liver, and a possible mechanism was antioxidative capacity.