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陈佳鹏, 林刚, 周宝森. 农药暴露与女性乳腺癌的相关性研究[J]. 中国公共卫生, 2004, 20(3): 289-290.
引用本文: 陈佳鹏, 林刚, 周宝森. 农药暴露与女性乳腺癌的相关性研究[J]. 中国公共卫生, 2004, 20(3): 289-290.
CHEN Jia-peng, LIN Gang, ZHOU Bao-sen. Correlation between pesticides exposure and morbidity and mortality of breast cancer[J]. Chinese Journal of Public Health, 2004, 20(3): 289-290.
Citation: CHEN Jia-peng, LIN Gang, ZHOU Bao-sen. Correlation between pesticides exposure and morbidity and mortality of breast cancer[J]. Chinese Journal of Public Health, 2004, 20(3): 289-290.

农药暴露与女性乳腺癌的相关性研究

Correlation between pesticides exposure and morbidity and mortality of breast cancer

  • 摘要:
      目的   分析环境中农药暴露与农业人群女性乳腺癌发病率和死亡率之间的相关关系。
      方法   收集沈阳市郊区(县)1990~2000年农药使用量资料和2000年研究地区女性乳腺癌发病和死亡资料。以1990~2000年11年平均的农药使用密度为自变量, 以2000年女性乳腺癌年龄别发病率和死亡率为因变量, 使用SPSS10.0统计软件进行Spearman等级相关及线性回归分析。
      结果   女性乳腺癌35~64岁年龄组发病率和死亡率均与农药使用密度显著正相关, 相关系数r(P值)分别为0829(0.042), 0.943(0.005)。以10岁为组距进行分析, 结果显示, 50~59岁年龄组发病率和40~49岁年龄组死亡率与农药使用密度的相关有显著性差异(P < 40.05), 相关系数r(P值)分别为0.829(0.042), 0.886(0.019)。线性回归分析显示, 35~64岁年龄组死亡率与农药平均使用密度之间存在剂量-反应关系, 回归系数是4.448(P < 0.05)。
      结论   环境中农药暴露与农业人群女性乳腺癌发病率和死亡率之间存在相关关系; 女性乳腺癌35~64岁年龄组死亡率与农药平均使用密度之间存在剂量-反应关系。

     

    Abstract:
      Objective   To make sure whether there is significant correlation between environmental pesticides exposure and breast cancer morbidity or mortality in agricultural women.
      Methods   To collect both using data of pesticides in suburban areas from 1990 to 2000 and breast cancer morbidity and mortality data of Shenyang in 2000.To regard pesticides using density of 11-year aver age as independent variable, age-group breast cancer morbidity and mortality as dependent varible, respectively.The coefficients of rank corrleation and linear regression between pesticides exposure and breast cancer morbidity and mortality are carried out by spss 10.0 statistical software.
      Results   The positive significant correlation is observed between pesticides using density and breast cancer morbidity and mortality in people of 35-64 age group, respectively.The coefficients of correlation and P value are 0.829(0.042), 0.943(0.005), respectively.Further analysis finds that 50-59 age group morbidity and 40-49 age mortality has significant positive correlation with pesticides using density.The coefficient of correlation and value are 0.829(0.042), 0.886(0.019), respectively.Simple regression analysis finds that significant doseresponse relation exists between 35-64 age mortality and pesticides using density.The regression coefficient is 4.448(P < 0.05).
      Conclusion   Environmental pesticides exposure is relative to morbidity and mortality of breast cancer in agricultural women.Linear relation is significant between 35-64 age mortality and pesticides using density.

     

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