学龄儿童β<sub>3</sub>-肾上腺素能受体基因变异的分布

莫宝庆; 李忠; 赵岩

学龄儿童β₃-肾上腺素能受体基因变异的分布

Distribution of beta 3-adrenergic receptor Trp64Arg mutation in school-aged children

摘要

摘要:
目的了解学龄儿童中β₃-肾上腺素能受体(β₃-AR)基因氨基酸序列第64位密码子上的色氨酸(Trp64Arg)变异型的分布特点及其与肥胖的关系。
方法用限制性片段基因长度多态性法对177名儿童进行了基因多态性检测, 同时测量身高、体重。
结果变异型等位基因(C)在被调查对象中出现的频率为0.240, 其中男童为0.226, 女童为0.267。肥胖女童中变异等位基因(C)、Trp64Arg变异基因型的出现频率明显高于正常体重者。有父母肥胖或有母亲肥胖的家庭中, 女童出现Trp64Arg变异的频率分别为70.3%, 71.4%。具有Trp64Arg变异儿童的体重、BMI明显较高, 具有Trp64Arg变异的女童发生肥胖的危险性为4.5。
结论基因Trp64Arg变异在学龄儿童中有一定的分布, 且以肥胖女童为多。

Abstract:
Objective To learn the distribution feature of beta 3-adrenergic receptor β(₃-AR)Trp64Arg mutation in school-aged children in Nanjing and its relationship with childhood obesity.
Methods β₃-AR Trp64Arg mutation was detected with the method of RFL P among 177 school children, their height and weight were measured.
Results The mutative C allee was 0.24 for all the children, 0.226 for boys and 0.267 for girls.The frequency of C allee and the genotype Trp64Arg was higher in obese girls.The frequency of the genotype Trp64Arg was 70.3%, 71.4% for obese girls with obese parents or obese mothers.Body weight and BMI of the children with β₃-AR Trp64Arg mutation were also higher.The risk for obesity in girls with β₃-AR Trp64Arg mutation was 4.5.
Conclusion There was distribution of β₃-AR Trp64Arg mutation in school-aged children in Nanjing, especially in obese girls.It may be related to obesity.

HTML全文

参考文献(11)

施引文献

资源附件(0)

学龄儿童β3-肾上腺素能受体基因变异的分布

Distribution of beta 3-adrenergic receptor Trp64Arg mutation in school-aged children

学龄儿童β₃-肾上腺素能受体基因变异的分布