高级检索
谢妮, 陈莹, 刘万洋, 董静, 刘振林, 陈杰. γ-干扰素对染石英尘大鼠肺纤维化的影响[J]. 中国公共卫生, 2004, 20(3): 314-315.
引用本文: 谢妮, 陈莹, 刘万洋, 董静, 刘振林, 陈杰. γ-干扰素对染石英尘大鼠肺纤维化的影响[J]. 中国公共卫生, 2004, 20(3): 314-315.
shu
XIE Ni, CHEN Ying, LIU Wan-yang, . Effect of γ-interferon on lung silicosis of rats exposed to quartz dust[J]. Chinese Journal of Public Health, 2004, 20(3): 314-315.
Citation: XIE Ni, CHEN Ying, LIU Wan-yang, . Effect of γ-interferon on lung silicosis of rats exposed to quartz dust[J]. Chinese Journal of Public Health, 2004, 20(3): 314-315.
shu

γ-干扰素对染石英尘大鼠肺纤维化的影响

Effect of γ-interferon on lung silicosis of rats exposed to quartz dust

    摘要
  • 摘要:
      目的   观察γ-干扰素(IFN-γ)对染石英尘大鼠肺脏器系数及羟脯氨酸含量的影响, 探讨γ-干扰素对实验性早期矽肺的防治作用。
      方法   一次性经气管给予雌性Wistar大鼠石英粉尘20mg/只, 染尘后第2d开始每天给予γ-干扰素(1×105IU/只), 分别在1个月和2个月时处死动物.观察大鼠肺脏器系数、肺羟脯氨酸含量变化。
      结果   给予γ-干扰素1个月及2个月时, 治疗组大鼠肺脏器系数与同期染尘对照组比较有所降低, 但无显著性差异; 而治疗组大鼠的肺羟脯氨酸含量均显著低于同期染尘对照组(P < 0.05)。
      结论   γ-干扰素可降低染石英尘大鼠肺羟脯氨酸含量, 提示对矽肺纤维化具有一定的防治作用。

     

    Abstract:
      Objective   To explore the preventive and therapeutic effect ofγ-interferon to experimental silicosis by studying the effect of γ-interferon on lung/body coefficient and hydroxyproline in rats exposed to quartz dust.
      Methods   Female Wistar rats were exposed to lower dose(20 mg/rat)of quartz dust by intratracheal injection.Beginning from the second day, the experimenatal rats were treated withγ-interferon(1×105 IU/rat)daily.Rats were killed after 1 and 2 month.Changes of lung/body coefficient and lung hydroxyproline content were determined.
      Results   The lung/body coefficient showed no significant difference between quartz control groups and treated groups.The lung hydroxyproline of treated groups were significantly lower than that of quartz control groups(P < 0.05).
      Conclusion   γ-interferon could significanlty reduce lung hydroxyproline content of quartz exposed rats.This denoted thatγ-interferon may inhibit or delay early silicotic fibrosis.

     

    • HTML全文
    • 参考文献(7)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回