电离辐射和丝裂霉素C诱导交叉适应性反应

Cross-resistant adapting response induced by radiation and mitomycin C

摘要:
目的探讨低剂量电离辐射和低浓度丝裂霉素C之间的交叉适应性反应规律。
方法以人淋巴细胞、小鼠骨髓细胞为实验材料, 分别用低剂量X射线或低浓度丝裂霉素C作适应性处理, 再用高浓度丝裂霉素C或大剂量X射线作攻击性处理。观察人淋巴细胞染色体畸变、微核、SCE, 小鼠骨髓细胞染色体畸变。
结果人淋巴细胞染色体畸变、SCE, 小鼠骨髓细胞染色体畸变分别呈现出低剂量X射线与低浓度丝裂霉素C的交叉适应性反应。
结论无论在离体条件下, 还是在哺乳动物体内, 低剂量辐射与低浓度丝裂霉素C之间存在着相互的交叉适应性反应现象。

Abstract:
Objective To probe the laws of the cross-adapting response induced by low dose radiation and low concentration mitomycin C.
Methods The human lymphocytes, bone marrow cells of mice were treated by low dose X-ray or low concentration mitomycin C before treated by high dose X-ray or high concentration mitomycin C.Some targets were observed, such as chromosome aberration of human lymphocytes, bone marrow cells of mice, micronuclear(MN), sister chromatied exchange(SCE).
Results The targets of above all appeared cross-adapt response.
Conclusion Cross-adapt response can be inducd by low dose radiation or by low concentration mitomycin C not only in vivo but also in vitro.