静脉药瘾者血源性病毒感染调查分析

李建蓉; 田昆仑; 王晶; 王一心; 郭利军

静脉药瘾者血源性病毒感染调查分析

Analysis on infection rates of blood transmission virus in intravenous drug users

摘要

摘要:
目的调查静脉药瘾者主要血源传播病毒HBV、HCV、HGV、巨细胞病毒(CMV)和单纯疱疹病毒(HSV)的感染率。
方法采用酶联免疫吸附法、放射免疫法、RT-PCR和荧光定量PCR法, 检测406例静脉药瘾者血清, 其中共用注射器者49.01%, 同时设立102例正常健康体检者作为对照。
结果静脉药瘾者HBV、HCV、HGV、CMV和HSV的感染率分别是36.45%, 69.7%, 1.97%, 2.71%和3.45%, 其中总感染人数321人(79.06%)和重叠感染人数128人(31.53%), 有共用注射器者单项感染率及重叠感染率均高于未共用者, 2者有显著性差异(P < 0.05)。对照组检测仅发现存在HBV感染(17.6%), 其余病毒感染指标均为阴性。
结论静脉药瘾者血源传播病毒感染率明显增高, 其中以HCV感染最为突出, 并且共用注射器是导致感染危险增大的要素。

Abstract:
Objective In order to assess the infection condition of HBV, HCV, HGV, HSV and CMY in Intravenous Drug Users(IVDUs).
Methods It is detected that anti-HBV, HCY, HGV, HSV, CMY markers by ELISA in 406 sera and 102 normal controls.While we detected HCV RNA by RT-PCR and Fluorescence Quantitative PCR methods.
Results Anti-HGV, HSV and CMV positive is 1.97%, 2.71% and 3.45% respctively, total HBV infection rate is 36.45%, HBsAg carrier 5.91%, HBeAg positive 3.96% in IVDUs.HBV infection rate is 17.65%, HBsAg carrier 0.98%, HBeAg positive 1.96% in the controls.Others are negative.The infection rates and coinfection rates are very prominent in the injector cousers of IVDUs(49.01%).
Conclusion It indicates that IVDUs is high risk population of blood transmission virus infection, especially HCV infection.

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