孕哺期染铅致幼鼠中枢系统氧化损伤的研究

Study of lipid peroxidation on brain of rat offspring exposed to lead

摘要:
目的探讨铅致哺乳期幼鼠中枢神经系统氧化损伤作用.
方法通过大鼠孕期及哺乳期不同剂量进行铅染毒, 测定出生后21d幼鼠脑的脂质过氧化物(LPO)水平, 还原型谷胱甘肽(GSH)含量及超氧化物歧化酶(SOD)、还原型谷胱甘肽过氧化酶(GSH-PX)、过氧化氢酶(CAT)活力.
结果中、高剂量染铅组脑组织LPO水平升高、SOD活力下降; 中剂量染铅组CAT活力下降.
结论重金属毒物铅可有通过增强脑组织脂质过氧化过程而致发育期神经系统的损伤.

Abstract:
Objective To study the lipid perox idation on developmental central nervous system.
Methods LPO level, the GSH content, and the activity of SOD, CAT, GSH-PX in the brain of rat offsprings exposed to lead during pregnant and breast-feed period were determined.
Results The LPO level in middle and high lead-exposed groups increased and the SOD activity decreased compared with the control, the activity of CAT in high lead-exposed group decreased.
Conclusion Lead ex erted developmental neurotoxicity through lipid peroxidation.