复方虫草对镉致雄性大鼠性激素水平的影响

曹建平; 廖惠珍; 王文祥; 闫平

复方虫草对镉致雄性大鼠性激素水平的影响

Effects of compound cordyceps sincesis(CCS) against cadmium-induced sexual hormones in male rats

摘要

摘要:
目的观察复方虫草菌丝粉对镉致雄性大鼠血清性激素水平的影响.
方法大鼠皮下注射氯化镉(按镉计1.0mg/kg), 同时按1%体重经口给予复方虫草菌丝粉(2.5%, 5.0%、10%), 采用放射免疫分析法测定血清睾酮(T)、卵泡刺激素(FSH)和黄体生成素(LH), 并进行精子质量分析.
结果 CdCl₂可使大鼠精子活动率、计数、睾丸绝对重量和脏器系数降低(P < 0.05), 精子畸形率增高(P < 0.05), 降低了大鼠血清T水平(P < 0.05);高剂量虫草可以提高精子活动率、计数、睾丸重量和脏器系数(P < 0.05), 降低精子畸形率(P < 0.05);提高大鼠血清水平(P < 0.05);但各组大鼠血清FSH、LH水平无显著性差异(P > 0.05).
结论复方虫草菌丝粉对镉致雄性生殖毒性有良好的拮抗作用.

Abstract:
Objective To investigate effects of compound cordyceps sinesis(CCS)against cadmium-induced serum sexual hormons in male rats.
Methods Rats were injected CdCl with a dose of 1 mg/(kg#wight), at the same time the rats were given with 2.5%, 5%, 10% CCS(1ml/100g).The serum testosterone, follicle stimulating hormone and luteinizing hormone were determined by radioimmunoassay, and the quality of serum were examined.
Results A significant reduction in the weight of the testis, the sperm population, motility of the epididymis were recorded in rats treated with cadmium alone.This was accompanied by an increase of malforme sperm in epididymis.High-dose CCS given resulted in partial recovery of the reproductive parameters studied(P < 0.05).A significant lower serum testosterone concentration was recorded in rats treated with CdCl₂ alone(P < 0.05).High-dose CCS could increase serum testosterone level as compared with CdCl₂ alone group(P < 0.05).
Conclusion CCS extract exerted striking protective effecs on cadmium-induced reproductive toxicity.

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