人参茎叶皂甙提高机体热耐受能力作用

李敏; 凌昌全; 沈志雷; 黄雪强

人参茎叶皂甙提高机体热耐受能力作用

Study on mechanism of ginsenosides in strengthening organic heat tolerance

摘要

摘要:
目的探索人参茎叶皂甙(Ginsenosides, GSS)增强机体热耐受能力的作用机制。
方法雄性SD大鼠随机分成热损伤组和对照组, 热损伤组分别灌喂20, 10, 5mg/mlGSS水溶液和蒸馏水, 2ml×10d。采用放免法测下丘脑、垂体β-EP含量、血浆β-EP、ACTH和皮质酮的含量。
结果 (1) 热损伤+20mg/mlGSS组下丘脑β-EP含量明显高于单纯热损伤组(P < 0.05)、热损伤+20mg/ml、热损伤+10mg/mlGSS组垂体β-EP含量没有降低(P > 0.05)。10mg/ml组还明显升高(P < 0.05);(2)热损伤+GSS各组大鼠血浆ACTH和GC含量与单纯热损伤组比没有明显变化。
结论 GSS可提高机体高温耐受能力, 其作用机制可能与调节下丘脑、垂体和血浆β-EP的含量有关, 并可能存在一个最佳剂量

Abstract:
Objective To study the mechanism of GSS strengthening organic heat tolerance.
Methods Rats were divided into heat-injured group and the control group.The rats in heat-injured groups were fed by 20, 10, 5 mg/ml GS and distilled water separately, 2 ml×10 d.The content of β-EP in hypothalamic, pituitary, plasma, ACTH and GC in plasma were determined by the radioimmunassay.
Results (1) The concentration of β-EP in hypothalamic was higher in heat-injured +20 mg/ml GSS group than that in heat-injured group(P < 0.05).The concentration of β-EP in pituitary was higher in heat-injured+20, 10 mg/ml GSS group than that in heat-injured group(P < 0.05, P < 0.01).The concentration of β-EP in plasma was higher in heat-injured+10 mg/ml GSS group than that in heat-injured group(P < 0.05).(2)The plasma concentration of ACTH and GC was not altered by GSS.
Conclusion Adjustment of concentration of hypothalamic, pituitary, plasma B-EP may be one of the mechanisms of GSS streng thening or ganic heat to lerance.Perhaps it would be the best dosage ginsenosides.

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