高级检索
李朋, 朱万孚, 何忠平, 庄辉. 血液透析肾病患者GBV-C感染的分析[J]. 中国公共卫生, 2003, 19(8): 911-913.
引用本文: 李朋, 朱万孚, 何忠平, 庄辉. 血液透析肾病患者GBV-C感染的分析[J]. 中国公共卫生, 2003, 19(8): 911-913.
shu
LI Peng, ZHU Wan-fu, HE Zhong-ping, . GBV-C infection in hemodialysis patients[J]. Chinese Journal of Public Health, 2003, 19(8): 911-913.
Citation: LI Peng, ZHU Wan-fu, HE Zhong-ping, . GBV-C infection in hemodialysis patients[J]. Chinese Journal of Public Health, 2003, 19(8): 911-913.
shu

血液透析肾病患者GBV-C感染的分析

GBV-C infection in hemodialysis patients

    摘要
  • 摘要:
      目的   探讨血液透析病人中GBV-C(GBV-C/HGV)感染情况及GBV-C的致病性。
      方法   对北京地区67例因肾功能衰竭而进行血液透析的患者血清, 用PCR法检测HCVRNA, GBV-CRNA和HBVDNA。同时应用ELISA法检测HBsAg和抗-HCV。
      结果   67例患者血清GBV-CRNA的检出率为16.42%, HBVDNA的检出率为26.87%, HCVRNA的检出率为22.39%, GBV-C和HCV的感染率随透析次数的增多而增高。在单独感染GBV-C的血液透析患者中未发现血清ALT或AST异常。
      结论   GBV-C的感染率随透析时间的延长而增高, 提示血液透析可能是GBV-C的传播途径之一。未发现经血液透析获得单独GBV-C感染者的血清转氨酶异常, 证明GBV-C很可能不具有嗜肝致病性。

     

    Abstract:
      Objective   To study the prevalence of GBV-C and the clinical significance of GBV-C in hemodialysis patients.
      Methods   Sixty-seven hemodialysis patients were enrolled in this study and HBV DNA, HCV RNA and GBV-C RNA were detected by PCR.Meantime, serum markers for hepatitis B and C were detected with commercially available enzyme-linked immunosorbent assay kits.
      Results   The prevalence of GBV-C in 67 hemodialysis was 16.42%, and the prevalence HCV and HBV among the hemodialysis patients was 22.39% and 26.87% respectively.The detection rate of GBV-C and HCV viremias increased with duration of hemodialysis.Serum alanine aminotransferase(ALT and AST)were elevated in patients with HCV or HBV viremia but not in patients with GBV-C viremia.
      Conclusion   The hemodialysis procedures seemed to be crucial for the transmission of GBV-C.The pathogenic effects of GBV-C on hepatitis appeared to be limited.

     

    • HTML全文
    • 参考文献(10)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回