高级检索
钟振伟, 胡利人. 低铅染毒对大鼠脂质过氧化作用的影响[J]. 中国公共卫生, 2003, 19(8): 1000-1001.
引用本文: 钟振伟, 胡利人. 低铅染毒对大鼠脂质过氧化作用的影响[J]. 中国公共卫生, 2003, 19(8): 1000-1001.
shu
ZHONG Zhen-wei, HU Li-ren. Effects of being poisoned by low level of lead on peroxidation of endoirine in rats[J]. Chinese Journal of Public Health, 2003, 19(8): 1000-1001.
Citation: ZHONG Zhen-wei, HU Li-ren. Effects of being poisoned by low level of lead on peroxidation of endoirine in rats[J]. Chinese Journal of Public Health, 2003, 19(8): 1000-1001.
shu

低铅染毒对大鼠脂质过氧化作用的影响

Effects of being poisoned by low level of lead on peroxidation of endoirine in rats

    摘要
  • 摘要:
      目的   探讨长期低铅染毒对大鼠内分泌脂质过氧化作用及超氧化歧化酶活性的影响。
      方法   将40只大鼠随机分成4组, 分别给予含有不同剂量的铅饲料8周, 测定并分析大鼠染毒后血中、甲状腺、胰腺组织中的铅含量、MDA、T-SOD、CAT、GSH-Px含量, 并进行相关分析。
      结果   各组血铅随染铅剂量升高而升高; 甲状腺、胰腺组织中的MDA含量随染铅剂量升高而升高, 并与血铅浓度呈正相关; 而甲状腺、胰腺组织中的T-SOD和GSH-Px含量随染铅剂量升高而下降, 并与血铅浓度呈负相关; 甲状腺、胰腺组织中的CAT与染铅剂量无关。
      结论   慢性铅中毒增强机体的脂质过氧化作用, 降低机体抗氧化酶系活力, 可能参与了体内某些内分泌功能和组织学的损害机制。

     

    Abstract:
      Objective   To observe effects of lipid perox idation and superoxide dismutase of endocrine in rats chronically poisoned with low levels of lead.
      Methods   Forty rats were randomly divided into four groups.They received lead diets of different levels for eight weeks.Serum level of lead MDA, T-SOD, CAT, GSH-Px in blood thyroid and pancreas are measured and analysed after the rats are poisoned.
      Results   The levels of blood lead in all groups increased with the lead dose.The levels of MDA increased with the lead dose and were correlated positively with the levels of blood lead in the thyroid and pancreas.The levels of T-SOD and GSHPx decreased with the lead dose and were correlated negatively with the levels of blood lead in the thyroid and pancreas.The levels of CAT had no correlation with the levels of blood lead in the thyroid.
      Conclusion   The chronic lead poisoning increased the effect of lipid perox idation and decreased the vitality of anti-oxidase, which may be a part of some endocrine functions and the harm mechanism of histology.

     

    • HTML全文
    • 参考文献(6)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回