乙肝免疫球蛋白阻断乙肝宫内传播的研究

Study on blocking function of HBIG on intrauterine infection of HBV

摘要:
目的研究阻断乙肝宫内传播的措施, 观察其效果。
方法对162例HBsAg阳性孕妇产前3个月注射乙肝免疫球蛋白(HBIG), 每月1次, 每次200U, 新生儿出生后采股静脉血, 检测HBV血清学标志, 观察HBV宫内感染率, 并和196例未注射HBIG孕妇相比较。
结果注射HBIG组的宫内感染率为1.85%, 低于未注射HBIG组561%, 差异未达到显著性水平(χ²=3.33, P=0.068)。未发现注射HBIG对母亲及新生儿有不良反应。
结论初步提示HBsAg阳性孕妇产前注射HBIG可能降低HBV宫内感染的发生。

Abstract:
Objective To study the effect of HBIG on HBV intrauterine infection during pregnancy of HBsAg female carrier.
Methods 162 patients were treated with HBIG 200 IU every month from week 28.Intrauterine infection of HBV were studied by detecting HBsAg in newborns in 24 hours after birth.The results of group with HBIGwere compared with the previous results of 196 cases without HBIG as control.
Results The HBsAg positive rate of the newborns in HBIG group was 1.85% and that of control group was 5.61% (χ²=3.33, P=0.068).No adverse reaction were discovered on mothers and newborns.
Conclusion The intrauterine infection of HBV possibly could be decreased by using HBIG during pregnancy.