高血糖、内皮素-1水平对大鼠视网膜的影响

刘艳; 罗志忠; 隋虹; 李兴洲; 李康; 卢明俊

高血糖、内皮素-1水平对大鼠视网膜的影响

Influence of blood sugar and endothelin-1 level on rats' retina

摘要

摘要:
目的光镜下观察高糖大鼠视网膜早期形态学改变并探讨其与血糖、内皮素-1水平的关系。
方法腹腔注射四氧嘧啶复制高糖大鼠模型, 应用放射免疫方法检测血浆内皮素-1水平, 并用血糖测量仪测定血糖, 同时观察大鼠视网膜形态学改变。
结果随着病程的延长, 持续高血糖可引起大鼠血浆内皮素-1水平升高, 从而使视网膜结构在病变早期即可发生形态学改变。病程4周时, 光镜观察即可发现异常, 病程6周时病变更加严重。
结论内皮素-1可能参与了糖尿病性视网膜病变的病理过程。在视网膜病变临床症状出现前, 已有亚临床的改变。

Abstract:
Objective To observe the early morphologic changes in hyperglycemia rats.retina by using light microscope, and to explore its relationship with blood sugar and endothelin-1(ET-1).
Methods The model of hyperglycemia rats were reproduced by injecting allox an monohydrate into abdominal cavity, ET-1 in plasma and blood sugar could be measured by radioimmunity methods and blood sugar instruments respectively, and moryhologic changes could be seen by light microscope.
Results With the prolongation of course, persistent hyperglycemia may result in the increase of ET-1 level in rats.plasam, so that the morphologic changes in retinal structure can occur in disease.s early phase.At the the 4th week, abnormal changes could be observed and it turned severe at the 6th week.
Conclusion ET-1 can participate in the pathologic process of diabetic retinopathy, which meant that the occurrence of subclinical changes may be ahead of clinical symptoms.

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