单纯性肥胖儿童瘦素、胰岛素及其相关性研究

张彩霞; 蒋卓勤

单纯性肥胖儿童瘦素、胰岛素及其相关性研究

Study on leptin, insulin and their relationships in simple obese children

摘要

摘要:
目的研究单纯性肥胖儿童瘦素、胰岛素及其相关关系。
方法对筛选出来的54名肥胖儿童和60名正常体重儿童进行瘦素、胰岛素、C-肽、血糖水平的测定, 并进行相关关系的研究。
结果肥胖组儿童瘦素、胰岛素、C-肽、血糖水平高于非肥胖组儿童, 胰岛素敏感性指数肥胖组儿童低于非肥胖组儿童, 差异有显著性意义(P < 0.05)。瘦素与体质指数、体脂百分比、体脂肪、臀围、胰岛素、C-肽浓度均呈显著正相关(P < 0.05), 与血糖、瘦体重、腰臀围比没有相关性。
结论肥胖儿童存在瘦素抵抗、高胰岛素血症和胰岛素抵抗, 瘦素与体质指数、胰岛素浓度呈显著正相关。

Abstract:
Objective To investigate serum leptin, insulin and their relationships in the simple obese children.
Methods Serum Leptin, insulin, C-peptide and fasting blood glucose were measured in 54 obese children and 60 non-obese children. At the same time, the relationship between leptin, obesity and insulin were studied.
Results Leptin, insulin, C-peptide, fasting blood glucose were much higher in obese children than in non-obese ones(P < 0.05), whereas insulin sensitivity index (IST) was much lower than that in non-bese children. Lept in was significantly correlated with BMI, %BF, BF, hip circumsference, insulin, C-peptide (P < 0.05). Leptin was not significantly correlated with blood glucose, LBM, WHR (P > 0.05).
Conclusion Obese children existed leptin resistance, hyperinsulinaemia and insulin resistance. Leptin was significantly correlated with BMI, insulin.

HTML全文

参考文献(4)

施引文献

资源附件(0)